Naslov
FUNCTIONAL COMMUNICATION OF SERYL-tRNA SYNTHETASE DOMAINS IN SUBSTRATE RECOGNITION

Autori
Weygand-Đurašević, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Godišnji sastanak hrvatskih biokemičara HB98 / Glavaš-Obrovac, Ljubica - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 1998

Skup
Godišnji sastanak hrvatskih biokemičara HB98

Mjesto i datum
Bizovac, Hrvatska, 17.09.1998. - 20.09.1998

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
tRNA:seryl-tRNA synthetase recognition

Sažetak
Aminoacyl-tRNAs are key components in protein synthesis. They are formed directly by correct acylation of tRNAs (Crick's hypothesis), or indirectly by tRNA-dependent transformation of misacylated tRNAs. Aminoacyl-tRNA synthetases (AARS) are involved in both types of processes. However, although the fundamental function of tRNA is to act as a specific amino acid carrier, these molecules are also essential for proofreading and editing out non-cognate amino acids by certain AARSs. We have recently elucidated an even more dynamic role of tRNA: seryl-tRNA synthetases (SerRS) recognize serine by a tRNA-dependent mechanism. This pathway, which may serve to increase the accuracy of serylation in vivo, is enabled by the functional communication of SerRS domains in substrate recognition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA