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Pregled bibliografske jedinice broj: 164971

Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus

Johansson, Cecilia; Zunec, Renata; García, Mercedes; Scherbarth, Hugo; Tate, Guillermo; Paira, Sergio; Navarro, Sandra; Perandones, Carlos; Gamron, Susana; Alvarellos, Alejandro et al.
Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus // Human genetics, 115 (2004), 230-238 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 164971 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus

Autori
Johansson, Cecilia ; Zunec, Renata ; García, Mercedes ; Scherbarth, Hugo ; Tate, Guillermo ; Paira, Sergio ; Navarro, Sandra ; Perandones, Carlos ; Gamron, Susana ; Alvarellos, Alejandro ; Graf, Cesar ; Manni, Jorge ; Berbotto, Guillermo ; Palatnik, Simon ; Catoggio, Luis ; Battagliotti, Cristina ; Sebastiani, Gian Domenico ; Migliaresi, Sergio ; Galeazzi, Mauro ; Pons-Estel, Bernardo ; Alarcón-Riquelme, Marta

Izvornik
Human genetics (0340-6717) 115 (2004); 230-238

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Systemic lupus erythematosus (SLE); microsatellites; genome scan

Sažetak
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies against intracellular components, the formation of immune complexes, and inflammation in various organs, typically the skin and kidney glomeruli. The etiology of the disease is not well understood but is most likely the result of the interaction between genetic and environmental factors. In order to identify susceptibility loci for SLE, we have performed genome scans with microsatellite markers covering the whole genome in families from Argentina, Italy, and Europe. The results reveal a heterogeneous disease with different susceptibility loci in different family sets. We have found significant linkage to chromosome 17p12-q11 in the Argentine set of families. The maximum LOD score was given by marker D17S1294 in combination with D17S1293, when assuming a dominant inheritance model (Z=3.88). We also analyzed a repeat in the promoter region of the NOS2A gene, a strong candidate gene in the region, but no association was found. The locus on chromosome 17 has previously been identified in genetic studies of multiple sclerosis families. Several other interesting regions were found at 1p35, 1q31, 3q26, 5p15, 11q23 and 19q13, confirming previously identified loci for SLE or other autoimmune diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
0108123

Ustanove:
Klinički bolnički centar Zagreb

Profili:

Avatar Url Renata Žunec (autor)

Citiraj ovu publikaciju:

Johansson, Cecilia; Zunec, Renata; García, Mercedes; Scherbarth, Hugo; Tate, Guillermo; Paira, Sergio; Navarro, Sandra; Perandones, Carlos; Gamron, Susana; Alvarellos, Alejandro et al.
Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus // Human genetics, 115 (2004), 230-238 (međunarodna recenzija, članak, znanstveni)
Johansson, C., Zunec, R., García, M., Scherbarth, H., Tate, G., Paira, S., Navarro, S., Perandones, C., Gamron, S. & Alvarellos, A. (2004) Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus. Human genetics, 115, 230-238.
@article{article, author = {Johansson, Cecilia and Zunec, Renata and Garc\'{\i}a, Mercedes and Scherbarth, Hugo and Tate, Guillermo and Paira, Sergio and Navarro, Sandra and Perandones, Carlos and Gamron, Susana and Alvarellos, Alejandro and Graf, Cesar and Manni, Jorge and Berbotto, Guillermo and Palatnik, Simon and Catoggio, Luis and Battagliotti, Cristina and Sebastiani, Gian Domenico and Migliaresi, Sergio and Galeazzi, Mauro and Pons-Estel, Bernardo and Alarc\'{o}n-Riquelme, Marta}, year = {2004}, pages = {230-238}, keywords = {Systemic lupus erythematosus (SLE), microsatellites, genome scan}, journal = {Human genetics}, volume = {115}, issn = {0340-6717}, title = {Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus}, keyword = {Systemic lupus erythematosus (SLE), microsatellites, genome scan} }
@article{article, author = {Johansson, Cecilia and Zunec, Renata and Garc\'{\i}a, Mercedes and Scherbarth, Hugo and Tate, Guillermo and Paira, Sergio and Navarro, Sandra and Perandones, Carlos and Gamron, Susana and Alvarellos, Alejandro and Graf, Cesar and Manni, Jorge and Berbotto, Guillermo and Palatnik, Simon and Catoggio, Luis and Battagliotti, Cristina and Sebastiani, Gian Domenico and Migliaresi, Sergio and Galeazzi, Mauro and Pons-Estel, Bernardo and Alarc\'{o}n-Riquelme, Marta}, year = {2004}, pages = {230-238}, keywords = {Systemic lupus erythematosus (SLE), microsatellites, genome scan}, journal = {Human genetics}, volume = {115}, issn = {0340-6717}, title = {Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus}, keyword = {Systemic lupus erythematosus (SLE), microsatellites, genome scan} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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