Naslov
Prognostic value of IL-5 in sinus lavage in patients with chronic maxillary sinusitis

Autori
Drviš, Petar ; Kalogjera, Livije ; Baudoin, Tomislav

Izvornik
Acta clinica Croatica (0353-9466) 42 (2003), 4; 315-319

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic rhinosinusitis; endosinusal treatment; IL-5; subjective outcomes

Sažetak
Abstract The aim of the study was to evaluate subjective outcomes in patients with chronic rhinosinusitis (CRS) after steroid/antibiotic endosinusal treatment and to test the hypothesis that pretreatment levels of cytokine, interleukin-5 (IL-5) in sinus fluid could predict response to endosinusal steroid/antibiotic treatment. Twenty-four patients with symptoms of CRS were recruited for the study. Inclusion criteria were sinusitis symptoms more than three months and mucosal thickening of the maxillary sinus mucosa > 6 mm, so it was considered as maxillary sinusitis. Patients with asthma, polyposis, recent infection, systemic steroid therapy or previous sinus surgery were excluded. Patients were treated endosinusally with 2 mg dexamethasone and 40 mg gentamycine per maxillary sinus for 5 days. Patients rated nasal / CRS disease-specific symptoms and completed a self-administered questionnaire concerning sinusitis symptoms at inclusion and after 30 days. Sinus lavage, collected at inclusion, was analysed for IL-5 concentration. Ten patients (52.6 %) had improvement after endonasal treatment with decrease in symptoms (responders), and nine (47.4 %) were unchanged or worsened after treatment (non-responders). Significant improvement was noted for overall sinusitis symptoms score for the overall sinusitis symptoms score (p=0.02) and for obstruction, postnasal drip, headache, sneezing and cough (p< 0.05) for the whole study group. There is positive correlation between baseline IL-5 level in sinus lavage and improvement rate of overall sinusitis symptoms score (p<0.01) and improvement rate of nasal secretion score (p<0.01). Results indicate that increased IL-5 levels in sinus fluid predict a good response to endosinusal steroid/antibiotic treatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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