Naslov
Fibrinolytic and anticoagulative activities from the earthworm Eisenia foetida

Autori
Hrženjak, Terezija ; Popović, Maja ; Božić, Tamara ; Grdiša, Mira ; Kobrehel, Đorđe ; Tiška-Rudman, Ljerka

Izvornik
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (1096-4959) 119 (1998), 4; 825-832

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Eisenia foetida; serinske proteaze
(Eisena foetida; serine proteases)

Sažetak
Biologically active glycolipoprotein complex (G-90) isolated from whole earthworm tissue extract shows anticoagulative and fibrinolytic activities. We isolated two tyrosine like serine peptidases with molecular masses of 34 kDa (P I) and 23 kDa (P II), respectively. P I peptidase is autocatalytically degraded to P II. Both peptidases exhibit fibrinolytic and anticoagulative activities. The activity of P I is much higher. P I in concentration of 105 ng/ml of plasma shortened the physiological time of fibrin clot lysis by 54% and completely inhibited blood clotting at a concentration of 103 ng/ml of venous blood.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA