Naslov
DISTRIBUTION OF HLA ALLELES AMONG CHILDREN WITH HAEMATOLOGICAL MALIGNANCIES IN CROATIA

Autori
Čečuk-Jeličić, Esma ; Martinez, Natalija ; Žunec, Renata ; Rajić, Ljubica ; Brkljačić-Kerhin, Vesna

Izvornik
Genes and immunity (1466-4879) 5 (2004);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
HLA; CHILDREN; HAEMATOLOGICAL MALIGNANCIES

Sažetak
It has been reported about association between some haematological malignancies and HLA. The aim of this study was to analyse HLA class I and class II in the group of 134 children (ALL=55 ; Neuroblastoma=32 ; AA=25 ; AML=17 ; CML=5), with mean age of 3.3 yrs. All patients and controls were tested for HLA-A, and – B antigens using MLCT method, while polymorphism at DRB1 was determined by PCR-SSP method. In the group of patients with ALL the most interesting findingwas a significantly lower frequency of B7 antigen (1.7% vs 9.6 ; p=0.003), while rest of HLA specificities were present with similar frequency as in controls. The only difference between children with AA and controls was the absence of allele DRB1*04 (p=0.007). Among patients with neuroblastoma at HLA-B locus, allele B38 (3.1% vs 6.7%) showed lower frequency but without statistical significance, while the difference in frequency for alleles B51 (4.6% vs 12.0% ; p=0.045) and B39 (7.8% vs 1.6% ; p=0.012) reached statistical significance. At DRB1 locus, difference was found for DRB1*0301 (17.1% vs 8.3% ; p=0.027) and DRB1*1201 (6.2% vs 1.4% ; p=0.032). We did not observe any difference in frequency of HLA-A in any of the studied groups in comparison to controls. The results of this study should be considered as preliminary and it is necessary to enlarge a group of patients for final conclusion. It would also be helpful to analyse other HLA loci as well as HLA haplotypes for better drawing of the genetic picture of children’ s haematological malignancies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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