Naslov
PSORIATIC ARTHRITIS: THE MICA-A4 TRIPLET REPEATS POLYMORPHISM IN THE TRANSMEMBRANE REGION CONFERS ADDITIONAL RISK FOR DEVELOPMENT OF DISEASE IN THE CROATIAN POPULATION

Autori
Grubić, Zorana ; Perić, Porin ; Čečuk-Jeličić, Esma ; Žunec, Renata ; Štingl, Katarina ; Ćurković, Božidar ; Brkljačić-Kerhin, Vesna

Izvornik
European journal of immunogenetics (0960-7420) 31 (2004); 93-98

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HLA alleles; psoriatic arthritis; D6S265; D6S273; MICA; MIB

Sažetak
The aim of this study was to investigate possible difference in the frequency of the alleles at HLA loci and microsatellite loci within the HLA region among patients suffering from psoriatic arthritis (PsA) and healthy controls. Fifty-eight Croatian PsA patients, 28 males and 30 females, and 157 healthy unrelated controls were typed for the HLA alleles (A, B, Cw, and DRB1) by the PCR-SSP method, while microsatellite alleles (D6S265, D6S273, MICA, and MIB) were analysed by electrophoresis in an ALFexpress sequencer. The findings from this study were: (1) the frequency of B*39 and B*57 was significantly increased in PsA patients ; (2) the frequency of B*13 and B*27 alleles did not show statistically significant p value after correction ; (3) B*0702, B*18, and B*38 alleles were decreased in patients only before correction ; (4) none of the alleles on other tested HLA loci were associated with PsA in Croatia ; (5) polymorphism at D6S265, D6S273, and MIB microsatellites among patients did not show any statistically significant difference when compared to controls ; (6) the increase of MICA-A4 allele in PsA patients was independent of B*39 and B*57 alleles.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA