Naslov
Role of the immune system in development of bone phenotype associated with generalised lymphoproliferative disorder in mice

Autori
Lukić, Ivan Krešimir ; Grčević, Danka ; Kovačić, Nataša ; Katavić, Vedran ; Marušić, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the Annual Meeting of the Croatian Immunological Society / Jonjić, Stipan - Rijeka, 2004, 24-24

Skup
Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Opatija, Hrvatska, 08.10.2004. - 10.10.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone ; mice ; immune system

Sažetak
We aimed to determine if the increased bone mass in mice with generalized lymphoproliferative disorder (gld), due to non-functional Fas-ligand , was a consequence of their autoimmune disorder, characterised by accumulation of double negative T cells (dnT) and production of autoantibodies. Parabiosis surgery was peformed betwen gld and wild-type mice. The jopint circulation in parabiosis leads to transfer of dnT cells from gld to wild-type animals and their homing to lympatic organs. Subsequent changes in the number of bone specific cells in bone marrow cultures of wild-type mice indicate that the bone phenotype of gld mice might be caused by their autoimmune disorder.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA