Naslov
Ochratoxin A-induced apoptosis in rat kidney tissue

Autori
Domijan, Ana-Marija ; Peraica, Maja ; Ferenčić, Željko ; Čužić, Snježana ; Fuchs, Radovan ; Lucić, Ana ; Radić, Božica

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 55 (2004), 4; 243-248

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
endemic nephropathy; necrosis; proximal tubules

Sažetak
The aim of our study was to find whether ochratoxin A (OTA) induces the apoptosis and/or necrosis of kidney tissue in rats. In the first experiment, the highest number of apoptotic cells was found in rats sacrificed one day after OTA administration (1.00 mg/kg b.w., i.p.). The number of apoptotic cells reduced gradually and they were not seen nine day after OTA administration. A possible dose-dependence of histological changes was checked in kidney tissue of rats given 0.25, 0.50 or 1.00 mg of OTA/kg b.w., i.p. three times a week for four weeks. The number of apoptotic cells showed a clear dose-dependence, but necrosis was absent even at the highest dose. The time-dependent appearance of lesions related to OTA administration was checked by administering 0.50 mgOTA/kg body weight to rats, and sacrificing them one day after 1, 3, 6, and 9 doses/administrations, or 6 and 21 day after 12 doses/administrations. Long-term administration is associated with continued and increased apoptosis without necrosis, suggestive of OTA's role in the pathogenesis of progressive renal atrophy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA