Naslov
Serum aluminium and accidental poisoning of dialysed patients

Autori
Blanuša, Maja ; Kostial, Krista

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of Abstracts of the International Symposium Metals, Environment, Health / Dobosz, Agnieszka - Szklarska Poręba : Wroclaw Medical University, Faculty of Chemistry, University of Wroclaw, 2004, 15-15

Skup
International Symposium Metals, Environment, Health

Mjesto i datum
Szklarska Poręba, Poljska, 24.06.2004. - 27.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Plasma; aluminium; dialysis; DFO; L1

Sažetak
Aluminium in serum of normal human population is extremely low, inspite of high aluminium prevalence in the environment. It does not poses any problem for normal healthy population, because of its very low absorption from the gastrointestinal tract (only about 1%). In patients with chronic renal failure, however it appears to be a great problem. In those patients it can enter the circulation through dialysis and cause encefalopathy, osteomalatic dialysis osteodystrophy and anemia [1]. Aluminium in dialysate originates often from water which has been purified by addition of aluminium salt as floculant. However, even low level contamination of water with aluminium given to dialysed patients for a long period of time as well as antacids therapy given orally, causes higher body burden of aluminium in such patients. Therefore, control of water used for preparation of dialysing solutions and serum of patients is neccessary. Method which is most often used for quantitative analysis of aluminium is electrothermal atomic absorption spectrometry. The method and its verification will be described, as well as results of aluminium measurement of water used for preparing dialysate and serum of patients after an accidental aluminium poisoning in a Croatian dialysis centre [2]. In cases of aluminium poisoning therapy with chelating agent desferrioxamine (DFO) is used [3]. The efficiency of a new chelating agent 1, 2-dimethyl-3-hydroxypyrid-4-one (L1) is now also evaluated. An experimental study on treatment with DFO and L1 to remove aluminium from the body was tested in acute rat model. The results of mono- and combined therapy with these two chelators will be presented [4]. References: [1] E.H. Jeffery: Biochemical mechanisms of aluminum toxicity. In: R.A. Goyer, M.G. Cherian (eds.) Toxicology of Metals, Berlin, Springer Ferlag, 1995, p. 139-161. [2] M. Blanuša, Lj. Prester, et al. Aluminium in water for preparation of dialysate and in serum of dialysed patients. Arh. hig. rada toksikol. 48, 197 (1997). [3] Consensus conference: Diagnosis and treatment of aluminium overload in end-stage renal failure patients. Nephrol. Dial. Transplant Suppl., 1, 1 (1993). [4] M. Blanuša, Lj. Prester et al. Chelation of aluminium by combining DFO and L1 in rats. Toxicology 147, 151 (2000).

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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