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 respiracijski distres sindrom (RDS) jedan je od velikih problema u modernom porodni\'9atvu. Incidencija RDSa je oko 1 \endash  2 %. RDS je posljedica nedovoljne produkcije surfaktanta, slo\'9eene tvari koja je odgovorna za sazrijevanje fetalnih plu\'e6
a. Najva\'9eniji \'e8imbenik nedovoljne produkcije surfaktanta i plu\'e6ne nezrelosti je skra\'e6enje trudno\'e6e tj. prijevremeni porod.
\par Antenatalna primjena kortikosteroida kao preventivni postupak koristi se vi\'9ae od trideset godina. Kortikosteroidi smanjuju incidenciju i jakost RDSa, smanjuju u\'e8estalost intracerebralnog krvarenja te smanjuju pobol i smrtnost novoro\'f0en\'e8
adi. Mehanizam djelovanja kortikosteroida sastoji se u poticanju proizvodnje surfaktanta te regulaciji plu\'e6ne intersticijske teku\'e6ine.
\par U ovom pregledu literature analiziramo pozitivne u\'e8inke te kratkoro\'e8ne i dugoro\'e8ne rizike }{\f1\lang1050\langfe1050\langnp1050\insrsid8666509\charrsid8666509 jednokratne i vi\'9aekratne antenatalne kortikosteroidne profilakti\'e8ke terapije.}{
\f1\lang1050\langfe1050\langnp1050\insrsid4154936\charrsid8666509 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid8666509\charrsid8666509 
\par Klju\'e8ne rije\'e8i: respiracijski distres sindrom (RDS), surfaktant, plu\'e6na maturacija, prijevremeni porod, kortikosteroidi  
\par }\pard\plain \s3\ql \li0\ri0\sl360\slmult1\keepn\nowidctlpar\faauto\outlinelevel2\rin0\lin0\itap0\pararsid8666509 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4154936\charrsid8666509 
\par }\pard \s3\ql \li0\ri0\sl360\slmult1\keepn\nowidctlpar\faauto\outlinelevel2\rin0\lin0\itap0 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12144859 Summary 
\par }\pard\plain \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9313130 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\lang1050\langfe1050\langnp1050\insrsid9313130\charrsid9313130 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid12144859 {\f1\insrsid12144859\charrsid12144859 Neonatal}{\f1\lang1050\langfe1050\langnp1050\insrsid12144859\charrsid4154936  }{\f1\insrsid12144859\charrsid12144859 
respiratory distress syndrome (RDS) is one of the biggest problems in modern obstetrics. The incidence of RDS is 1-2 %. }{\f1\insrsid12144859 
RDS is a condition of insufficient surfactant production. Surfactant is a complex molecule which is responsible for maturation of the fetal lungs. The most important factor for insufficient surfactant production and pulmonary immaturity is}{
\f1\insrsid273741  shortening of gestation, i.e. }{\f1\insrsid12144859 preterm delivery. 
\par Antenatal corticosteroids for maturation of the fetal lungs are in use for }{\f1\insrsid273741 over}{\f1\insrsid12144859  thirty years.}{\f1\insrsid273741 
 Corticosteroids decrease the incidence and intensity of RDS, decrease the severity of intracerebral hemorrhage and decrease overall neonatal}{\f1\insrsid8666509  morbidity and}{\f1\insrsid273741 
 mortality. The mechanism of corticosteroids action is probably induction of fetal pulmonary enzyme\rquote s complex}{\f1\insrsid8666509  that is responsible for adequate surfactant production }{\f1\insrsid273741 
and regulation of pulmonary interstitial fluids.
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9313130 {\f1\insrsid9313130\charrsid9313130 
In this literature review, we analyzed the long and short term benefits and risks of single and multiple antenatal corticosteroids use.
\par }{\f1\insrsid273741  }{\f1\insrsid9313130 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8666509 {\f1\insrsid9313130\charrsid8666509 Key words: respiratory distress syndrome, surfactant, pulmonary maturation, pr}{\f1\insrsid8666509\charrsid8666509 
eterm delivery, corticosteroids}{\f1\insrsid12144859\charrsid8666509 
\par }\pard\plain \s3\ql \li0\ri0\sl360\slmult1\keepn\nowidctlpar\faauto\outlinelevel2\rin0\lin0\itap0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12144859 
\par 
\par }\pard\plain \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8666509 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\lang1050\langfe1050\langnp1050\insrsid8666509 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par }{\lang1050\langfe1050\langnp1050\insrsid8666509\charrsid8666509 
\par }\pard\plain \s3\ql \li0\ri0\sl360\slmult1\keepn\nowidctlpar\faauto\outlinelevel2\rin0\lin0\itap0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12144859 
\par 
\par 
\par 
\par 
\par }\pard\plain \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8666509 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\lang1050\langfe1050\langnp1050\insrsid8666509 
\par 
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\par }{\lang1050\langfe1050\langnp1050\insrsid8666509\charrsid8666509 
\par }\pard\plain \s3\ql \li0\ri0\sl360\slmult1\keepn\nowidctlpar\faauto\outlinelevel2\rin0\lin0\itap0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 Uvod
\par }\pard\plain \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\b\f1\cf6\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid5708887 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid2503109 Novoro\'f0ena\'e8ki}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 
 respiracijski distres sindrom (RDS) ili novoro\'f0ena\'e8ka hiposurfaktoza, jedan je od ozbiljnijih p}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10511838 roblema u modernom porodni\'9atvu}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid733733 . RDS je
}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid2503109  uz }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4336340  infekciju naj\'e8e\'9a\'e6i uzrok novoro\'f0ena\'e8kog}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887  pobola i smrtnosti}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 . Od RDSa poboljeva 1 do 2 % novoro\'f0en\'e8}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9449822 adi}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520  [1]}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 RDS se javlja kao posljedica nedovoljnje produkcije surfaktanta}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10567963\charrsid10567963  (}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid15493364 dipalmitoil \endash  fosfatidil \endash  }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10567963\charrsid10567963 kolina)}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 , slo\'9eene tvari koju fetalna plu\'e6a u najve\'e6oj mjeri stvaraju u zadnjem tromjese\'e8ju trudno\'e6e i koja utje\'e8e na sazrijevanje plu\'e6a i prilagodbu ekstrauterinom \'9e
ivotu. Surfaktant, tvar koju prizvode pneumociti tipa II, odr\'9eava stabilnost alveolarne membrane, sprije\'e8avaju\'e6i pretjerano \'9airenje alveola na vrhuncu udaha \endash  inspirija i kolaps alveola na vrhuncu izdaha \endash  eks}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9963377 pirija te na taj na\'e8in omogu\'e6uje}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963  odvijanje normalne plu\'e6}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9449822 
ne funkcije \endash  disanja}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056  [1}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520 ]}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 .}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9449822 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 Nedovoljna produkcija surfaktanta i plu\'e6na nezrelost naj\'e8e\'9a\'e6e je povezana s kra\'e6im trajanjem gestacije, tj. ro\'f0enjem djeteta prije navr\'9aenih 37 tjedana trudno
\'e6e. Kako je u\'e8estalost prijevremenog poroda izme\'f0u 5 i 10 %, jasan je opseg problema i potreba }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887 za }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 unaprije\'f0
enjem njege i zdr}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid2297631\charrsid10567963 avstvene skrbi prijevremeno ro\'f0ene djece}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056  [1}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520 ]}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 . }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8194184 U ovom pregledu opisujemo dvojbe}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887  antenatalne primjene kortikosteroida u modernom porodni\'9atvu.
\par 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3959624 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
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\par 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887\charrsid5708887 Kortikosteroidi  }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887\charrsid5708887 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid1248627 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 Antenatalna primjena kortikostroida}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10567963  (KS)
}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963  u svrhu sazrijevanja fetalnih plu\'e6a te n}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid14881142 jihove prilagodbe izvan materni\'e8nom}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963  na\'e8inu \'9eivota prvi se puta kao pre}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10495697 ventivni terapijski postupak }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963  po\'e8ela primjenjivati 1972 godine}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056  [2}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520 ]}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid14952813 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12858579 T}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 im}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12858579  neinvazivn}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 im}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887  indirektnim}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 
 fetalnim}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid2498866  terapijskim}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627  postupkom}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887  jer se }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 KS se daju i}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5708887 ntramuskularno majci, ut}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 je\'e8emo}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627\charrsid1248627  }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627\charrsid10567963 na sazrijevanje fetalnih plu\'e6a i na taj na\'e8in smanjenje}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 mo}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627\charrsid10567963  u\'e8}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627 estalost}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1248627\charrsid10567963  RDSa.}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8194184 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963 KS najvjerojatnije pospje\'9auju sintezu fosfolipida te produkciju proteina koji su va\'9eni za sintezu surfaktanta. Tako\'f0
er sa smatra da KS mogu utjecati na kvalitativne i kvantitativne promjene plu\'e6nog intersticija, maturaciju i diferencijaciju stanica, inhibiciju sinteze DNK, stimulaciju antioksidantnih enzima te regulacij}{
\f1\lang1050\langfe1050\langnp1050\insrsid7739851 u metabolizma plu\'e6ne intersticijske teku\'e6ine}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056  [3]}{\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963 . }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid14952813 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid11560405 {\f1\lang1050\langfe1050\langnp1050\insrsid16254826 Deksametazon i betametazon su KS koji se danas antenatalno koriste u sprije\'e6avanju }{
\f1\lang1050\langfe1050\langnp1050\insrsid5708887 novoro\'f0ena\'e8kog pobola i smrtnosti.}{\f1\lang1050\langfe1050\langnp1050\insrsid3886991  Betametazon se koristi \'e8e\'9a\'e6e jer neki pripravci deksametazona kao konzervans sadr\'9e
e sulfite, za koje se smatra da}{\f1\lang1050\langfe1050\langnp1050\insrsid5443832  bi}{\f1\lang1050\langfe1050\langnp1050\insrsid3886991  mogli biti neurotoksi\'e8ni}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [4]}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886991 .}{\f1\lang1050\langfe1050\langnp1050\insrsid16254826  Ovi sintetski }{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 derivati glukokortikosteroida}{\f1\lang1050\langfe1050\langnp1050\insrsid16254826 
 imaju slabo imunosupresivno djelovanje i u svojoj aktivnoj formi prolaze p}{\f1\lang1050\langfe1050\langnp1050\insrsid13190685 ostelji\'e8nu barijeru. Postelji\'e8ni}{\f1\lang1050\langfe1050\langnp1050\insrsid16254826  enzimatski sustav djelomi\'e8
no transformira KS u inaktivne metabolite}{\f1\lang1050\langfe1050\langnp1050\insrsid11560405  tako da je koncentracija aktivnih metabolita KS u fetalnoj krvi (umbilikalnoj veni) oko 25-30% koncentracije KS u maj\'e8inskoj krvi}{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [5}{\f1\lang1050\langfe1050\langnp1050\insrsid4403520 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid11560405 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid4398289 {\f1\lang1050\langfe1050\langnp1050\insrsid3762343 Me\'f0utim koncentrcija KS u fetalnoj krvi opada, tako da je tjedan dana nakon primjene }{
\f1\lang1050\langfe1050\langnp1050\insrsid4398289 nemjerljiva. Zbog toga ostaje pitanje da li je}{\f1\lang1050\langfe1050\langnp1050\insrsid13190685  davanje jednokatne}{\f1\lang1050\langfe1050\langnp1050\insrsid10511838  antenatalne doze}{
\f1\lang1050\langfe1050\langnp1050\insrsid4398289  KS dovoljno }{\f1\lang1050\langfe1050\langnp1050\insrsid9967500 u\'e8inkovit}{\f1\lang1050\langfe1050\langnp1050\insrsid4398289  }{\f1\lang1050\langfe1050\langnp1050\insrsid13190685 profilakti\'e8
ki postupak u sprj}{\f1\lang1050\langfe1050\langnp1050\insrsid10511838 e\'e8}{\f1\lang1050\langfe1050\langnp1050\insrsid9967500 avanju nastanka}{\f1\lang1050\langfe1050\langnp1050\insrsid4398289  RDSa ili KS treba ponavljati svakih 7 \endash  14 dana da b
}{\f1\lang1050\langfe1050\langnp1050\insrsid9967500 i se}{\f1\lang1050\langfe1050\langnp1050\insrsid10511838  njihova}{\f1\lang1050\langfe1050\langnp1050\insrsid9967500  koncentracija odr\'9eavala}{\f1\lang1050\langfe1050\langnp1050\insrsid4398289  unutar
}{\f1\lang1050\langfe1050\langnp1050\insrsid9967500  granica terapijske u\'e8inkovitosti}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [6}{\f1\lang1050\langfe1050\langnp1050\insrsid4403520 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid4398289 . 

\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid16254826 {\f1\lang1050\langfe1050\langnp1050\insrsid10687677 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1990261 
\par 
\par 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 
\par }{\b\f1\lang1050\langfe1050\langnp1050\insrsid7884791 Indikacije i kontraindikacije za antenatalnu primjenu kortikosteroida
\par }{\b\f1\lang1050\langfe1050\langnp1050\insrsid12745067 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid12745067 {\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 A}{\f1\lang1050\langfe1050\langnp1050\insrsid15209467 ntenatalna primjena}{
\f1\lang1050\langfe1050\langnp1050\insrsid9114143  KS}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963  u stalnom je po}{\f1\lang1050\langfe1050\langnp1050\insrsid15209467 r}{
\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 astu}{\f1\lang1050\langfe1050\langnp1050\insrsid8194184  u}{\f1\lang1050\langfe1050\langnp1050\insrsid15209467  }{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 
posljednjih dvadesetak godina.}{\f1\lang1050\langfe1050\langnp1050\insrsid13190685  Godine}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963  1985 godine antenatalna KS profilaksa u svrhu postiz}{
\f1\lang1050\langfe1050\langnp1050\insrsid9114143 anja plu\'e6e zrelosti}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 , primjenjivala se tek u 8 % slu\'e8ajeva, 1990.}{\f1\lang1050\langfe1050\langnp1050\insrsid15209467 
 godine taj je posotak}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963  narastao na 20%, 1995.}{\f1\lang1050\langfe1050\langnp1050\insrsid15209467  godine}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 
 oko 52%, da bi se na po\'e8etku novog milenija profilakti\'e8ka upotreba KS}{\f1\lang1050\langfe1050\langnp1050\insrsid15009126  u slu\'e8aju indikacije }{\f1\lang1050\langfe1050\langnp1050\insrsid13190685  }{
\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 primjenjivala u vi\'9ae od 75 %}{\f1\lang1050\langfe1050\langnp1050\insrsid13190685  }{\f1\lang1050\langfe1050\langnp1050\insrsid4619657 [7}{
\f1\lang1050\langfe1050\langnp1050\insrsid1990261 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid10567963 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid16254826 {\f1\lang1050\langfe1050\langnp1050\insrsid15209467 Indikacije i kontraindikacije za antenatalnu primjenu KS prikazane su u tablici 1}{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [5}{\f1\lang1050\langfe1050\langnp1050\insrsid9916146 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid15209467 .}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid15009126 Prijevremeni porod}{\f1\lang1050\langfe1050\langnp1050\insrsid8194184  je naj\'e8e\'9a\'e6i uzrok novoro\'f0ena\'e8kog pobola i smrtnosti}{\f1\lang1050\langfe1050\langnp1050\insrsid9114143 
 pa su pravi i prijete\'e6i prijevremeni porod na\'e8je\'9a\'e6e indikacije za antenatalnu primjenu KS. Krvarenje u trudno\'e6i (naj\'e8e\'9a\'e6e placenta previja), prijevreme}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 no prsnu\'e6
e plodovih ovoja (PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid9114143 ) i svako drugo stanje koje zahtijeva prijevremeno dovr\'9aenje trudno\'e6e su tako\'f0er indikacije za primjenu KS}{\f1\lang1050\langfe1050\langnp1050\insrsid7884791 
, iako kod nekih od tih stanja postoje dvojbe o up}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 otrebi KS (primjena KS kod PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid7884791 a)}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [5}{
\f1\lang1050\langfe1050\langnp1050\insrsid12127776 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid16219126 .}{\f1\lang1050\langfe1050\langnp1050\insrsid9114143 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid6696398 {\f1\lang1050\langfe1050\langnp1050\insrsid16219126 
Kontraindikacije za antenatalnu primjenu KS su apsolutne i relativne. Postavljena sumnja ili dokazani korioamnionitis predstavlja apsolutnu kontraindikaciju za primjenu KS, jer u tom slu\'e8aju KS mogu zbog svog protuupalnog i imunosupresivnog djelovanja}
{\f1\lang1050\langfe1050\langnp1050\insrsid16219126\charrsid16219126  }{\f1\lang1050\langfe1050\langnp1050\insrsid16219126 poja\'e8ati intenzitiet }{\f1\lang1050\langfe1050\langnp1050\insrsid10511838 infekcije i sprije\'e8iti primjereni humoralni}{
\f1\lang1050\langfe1050\langnp1050\insrsid16219126  i stani\'e8}{\f1\lang1050\langfe1050\langnp1050\insrsid10511838 ni imunolo\'9aki odgovor na infekciju}{\f1\lang1050\langfe1050\langnp1050\insrsid16219126 
. Aktivna tuberkuloza te neki oblici sustavnih i hepatanih porfirija tako\'f0er predstavljaju apsolutnu kotraidikaciju za antenatalnu primjenu KS. }{\f1\lang1050\langfe1050\langnp1050\insrsid6696398 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid16219126 Od relativnih kontraindikacija }{\f1\lang1050\langfe1050\langnp1050\insrsid10566160 se navodi upotreba}{\f50\lang1050\langfe1050\langnp1050\insrsid6696398  tokolitika iz grupe \'e2}{
\f1\lang1050\langfe1050\super\langnp1050\insrsid15955782 2}{\f1\lang1050\langfe1050\langnp1050\insrsid6696398  agonista (}{\f1\lang1050\langfe1050\langnp1050\insrsid10566160 betasmpatikomimetika}{\f1\lang1050\langfe1050\langnp1050\insrsid6696398 
) ritodrina, terbutlalina, salbutamola}{\f1\lang1050\langfe1050\langnp1050\insrsid9963377 ,}{\f50\lang1050\langfe1050\langnp1050\insrsid6696398  jer KS u kombinaciji s \'e2}{\f1\lang1050\langfe1050\super\langnp1050\insrsid15955782 2}{
\f1\lang1050\langfe1050\langnp1050\insrsid6696398  agonistima, mogu pospje\'9aiti nastanak plu\'e6nog edema, najozbiljnije nuspojave tokolitika iz grupe}{\f50\lang1050\langfe1050\langnp1050\insrsid6696398  \'e2}{
\f1\lang1050\langfe1050\super\langnp1050\insrsid15955782 2}{\f1\lang1050\langfe1050\langnp1050\insrsid6696398  agonista. Tako\'f0er i primjena vi\'9aekratnih antenatalnih doza KS jo\'9a uvijek predstavlja relativnu kontraindikaciju}{
\f1\lang1050\langfe1050\langnp1050\insrsid7884791 ,}{\f1\lang1050\langfe1050\langnp1050\insrsid6696398  jer}{\f1\lang1050\langfe1050\langnp1050\insrsid7884791  nisu poznati svi potencijalni }{\f1\lang1050\langfe1050\langnp1050\insrsid14881142 kratkoro\'e8
ni i dugoro\'e8ni maj\'e8in}{\f1\lang1050\langfe1050\langnp1050\insrsid7884791 i, fetalni i neonatalni rizici uzrokovani vi\'9aekratnom antenatalnom KS profilakti\'e8kom terapijom}{\f1\lang1050\langfe1050\langnp1050\insrsid1990261  }{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657 [5}{\f1\lang1050\langfe1050\langnp1050\insrsid1990261 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid7884791 .
\par 
\par 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid3959624 {\f1\lang1050\langfe1050\langnp1050\insrsid3959624 
\par }{\b\f1\lang1050\langfe1050\langnp1050\insrsid3959624 
\par }{\b\f1\lang1050\langfe1050\langnp1050\insrsid7884791\charrsid2498866 Pozitivni u\'e8inci }{\b\f1\lang1050\langfe1050\langnp1050\insrsid7802497 jednokatne antenatalne doze kortikostroida}{\b\f1\lang1050\langfe1050\langnp1050\insrsid7884791 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid6696398 {\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid16219126 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9449822 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10511838 Najzna\'e8ajniji}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9449822  pozitivni u\'e8
inak antenatalne primjene KS je smanjenje u\'e8estalosti}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677  neonatalnog}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9449822  RDSa.}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9718187 {\f1\lang1050\langfe1050\langnp1050\insrsid7080352 Jednokratna doza KS (}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 betametazon}{
\f1\lang1050\langfe1050\langnp1050\insrsid3959624  a}{\f1\lang1050\langfe1050\langnp1050\insrsid10495697  2x12 mg im.}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963  ili }{\f1\lang1050\langfe1050\langnp1050\insrsid10687677 deks}{
\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 ametazon}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624  a}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963  }{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 2}{
\f1\lang1050\langfe1050\langnp1050\insrsid10495697 x}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 12}{\f1\lang1050\langfe1050\langnp1050\insrsid10495697  mg im. unutar 24 sata}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 )}{
\f1\lang1050\langfe1050\langnp1050\insrsid12745067  izme\'f0u 24 \endash  34 tjedna trudno\'e6e}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963  u usporedbi s placebom}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067 ,}{
\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963  statisti\'e8ki}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624  se}{\f1\lang1050\langfe1050\langnp1050\insrsid12279114  }{
\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 zna\'e8ajno}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624  povezuje}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963  sa sman}{
\f1\lang1050\langfe1050\langnp1050\insrsid10511838 jenjem u\'e8estalosti}{\f1\lang1050\langfe1050\langnp1050\insrsid7080352  RDSa (}{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 OR 0.53; CI [ 0.44}{
\f1\lang1050\langfe1050\langnp1050\insrsid10511838  \endash  0.63]}{\f1\lang1050\langfe1050\langnp1050\insrsid7080352 )}{\f1\lang1050\langfe1050\langnp1050\insrsid12279114  ako porod nastupi }{\f1\lang1050\langfe1050\langnp1050\insrsid9718187 izme\'f0u }{
\f1\lang1050\langfe1050\langnp1050\insrsid12279114 24 sata}{\f1\lang1050\langfe1050\langnp1050\insrsid9718187  i tjedan dana}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  od njihove primjene [8}{\f1\lang1050\langfe1050\langnp1050\insrsid12279114 ].}
{\f1\lang1050\langfe1050\langnp1050\insrsid9449822\charrsid10567963 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid16281191 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191 Osim smanjenja RDSa, jednokratno primjenjeni}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677\charrsid16281191  KS pozitivno djel}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3959624 uju na smanjenje u\'e8estalosti intrakranijalnog krvarenja (IKK)}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10511838\charrsid16281191  (}{\f1\lang1050\langfe1050\langnp1050\insrsid10511838\charrsid16281191 p < 0.05)}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid14881142 , novoro\'f0ena\'e8ke smrtnosti}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10511838\charrsid16281191  (}{\f1\lang1050\langfe1050\langnp1050\insrsid10511838\charrsid16281191 OR 0.66; CI [ 0.48 \endash  0.75])}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677\charrsid16281191 ,}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191  smanjuju}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11032379\charrsid16281191  potrebu}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677\charrsid16281191  za postnatalnom}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11032379\charrsid16281191  upotre}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677\charrsid16281191 bom surfaktanata i mehan}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191 i
\'e8kom ventilacijom}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4357107 ,}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107  pove\'e6avaju funkcionalni rezidualni volumen (FRV) i pasivnu plu\'e6nu rastegljivost \endash  complia}{
\f1\lang1050\langfe1050\langnp1050\insrsid10495697 n}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 ce (PPR}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 ) novoro\'f0ena\'e8kih plu\'e6a}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191  te pospje\'9auju}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677\charrsid16281191  ci}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11032379\charrsid16281191 
rkulatornu stabilnost}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4278953 ,}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191  jer}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11032379\charrsid16281191  }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191 u prva 24 sata \'9eivota, antenatalno primjenjeni KS uzrokuju povi\'9aenje krvnog tlaka i smanjuju upoteb}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4278953 u vazodilatatora i }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191 plazma}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191 -}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4278953 ekspandera}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid14881142  kod nedono\'9a\'e8adi}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4619657  [}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290 8,9,10}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4619657 
,11}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16281191\charrsid16281191 . }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10687677\charrsid16281191 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid13909763 {\f1\lang1050\langfe1050\langnp1050\insrsid13909763 Retrospektivne d}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 op}{
\f1\lang1050\langfe1050\langnp1050\insrsid4357107 lerske studije su pokazale da a}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 n}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107 t}{
\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 enatalno primjenjeni KS pove\'e6avaju protok u }{\f1\lang1050\langfe1050\langnp1050\insrsid13909763 fetalnoj }{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 mo\'9edano}{
\f1\lang1050\langfe1050\langnp1050\insrsid3959624 j cirkulaciji}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 , ali}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336  da}{
\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107  nemaju zna\'e8anijeg u\'e8inka na pove\'e6anje protok}{\f1\lang1050\langfe1050\langnp1050\insrsid10495697 a u umbilikalnim atrerijama i }{
\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 venskoj cirkulaciji}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [12}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 . Me\'f0
utim}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107  Potter i sur. su u svojoj prospekt}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 ivnoj studiji, }{\f1\lang1050\langfe1050\langnp1050\insrsid4357107 iznjeli }{
\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 zaklju\'e8ak da KS izravno uzrokuju vazodilataciju i }{\f1\lang1050\langfe1050\langnp1050\insrsid4357107 pove\'e8avaju}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 
 protok}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107  i}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107  koz umbilikalnu arteriju}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [13}{
\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid4357107\charrsid4357107 .  }{\f1\lang1050\langfe1050\langnp1050\insrsid13909763 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid12745067 {\f1\lang1050\langfe1050\langnp1050\insrsid16012863 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid12279114 {\f1\lang1050\langfe1050\langnp1050\insrsid12279114 I u}{\f1\lang1050\langfe1050\langnp1050\insrsid5259103  slu\'e8aju kada postoji sumnja da}{
\f1\lang1050\langfe1050\langnp1050\insrsid12279114  \'e6e}{\f1\lang1050\langfe1050\langnp1050\insrsid5259103  porod nastupi}{\f1\lang1050\langfe1050\langnp1050\insrsid12279114 ti}{\f1\lang1050\langfe1050\langnp1050\insrsid5259103  }{
\f1\lang1050\langfe1050\langnp1050\insrsid12279114 unutar}{\f1\lang1050\langfe1050\langnp1050\insrsid5259103  24 sata tako\'f0er treba }{\f1\lang1050\langfe1050\langnp1050\insrsid12279114 primjeniti KS jer je i}{
\f1\lang1050\langfe1050\langnp1050\insrsid7080352  nepotpuna doza KS (}{\f1\lang1050\langfe1050\langnp1050\insrsid14577989 12 mg, deks}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid12745067 ametazo}{
\f1\lang1050\langfe1050\langnp1050\insrsid12279114 na ili betametazona) povezana}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid12745067  s redukcijom}{\f1\lang1050\langfe1050\langnp1050\insrsid14577989  te\'9eih oblika}{
\f1\lang1050\langfe1050\langnp1050\insrsid3959624  IKK}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid12745067  III \endash  IV stupnja (OR 0.42; CI [0.19 - 0.92]; p = 0.03) i sm}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 
anjenjem novoro\'f0ena\'e8ke smrtnosti}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid12745067  (OR 0.31; CI [0.11 - 0.86]; p = 0.02)}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [14}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863 
]}{\f1\lang1050\langfe1050\langnp1050\insrsid12745067\charrsid12745067 .  
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid4346775 {\f1\lang1050\langfe1050\langnp1050\insrsid4346775 Alternativno rije\'9aenje}{\f1\lang1050\langfe1050\langnp1050\insrsid9987506  je}{
\f1\lang1050\langfe1050\langnp1050\insrsid4346775  }{\f1\lang1050\langfe1050\langnp1050\insrsid14424749 intrauterina}{\f1\lang1050\langfe1050\langnp1050\insrsid5639749  intramuskularna}{\f1\lang1050\langfe1050\langnp1050\insrsid14424749  }{
\f1\lang1050\langfe1050\langnp1050\insrsid3688385 KS terapija, terapijski postupak koji se po\'e8eo primjenjivati od 1996. godine. Tim}{\f1\lang1050\langfe1050\langnp1050\insrsid2769171  se}{\f1\lang1050\langfe1050\langnp1050\insrsid3688385 
 invazivnim terapijskim postupkom,}{\f1\lang1050\langfe1050\langnp1050\insrsid4346775  pod direktnom kontrolom ultrazvuka}{\f1\lang1050\langfe1050\langnp1050\insrsid2769171 ,}{\f1\lang1050\langfe1050\langnp1050\insrsid4346775  }{
\f1\lang1050\langfe1050\langnp1050\insrsid14424749 KS}{\f1\lang1050\langfe1050\langnp1050\insrsid2769171  (u dozi od 1 mg/kg ultrazvu\'e8no procijenjene tjelesne te\'9eine ploda) daju}{\f1\lang1050\langfe1050\langnp1050\insrsid4346775 
 intramuskularno fetusu}{\f1\lang1050\langfe1050\langnp1050\insrsid2769171  [1}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657 5}{\f1\lang1050\langfe1050\langnp1050\insrsid2769171 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid4346775 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid9767924    }{\f1\lang1050\langfe1050\langnp1050\insrsid14577989\charrsid9767924 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid12745067 {\b\f1\lang1050\langfe1050\langnp1050\insrsid3959624 
\par }{\b\f1\lang1050\langfe1050\langnp1050\insrsid3959624\charrsid3959624 Rizici antenatale primjene kortikosteroida}{\b\f1\lang1050\langfe1050\langnp1050\insrsid2102669 
\par }{\b\f1\lang1050\langfe1050\langnp1050\insrsid3959624\charrsid3959624 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid15955782 Rizici se prema vremenu nastanka mogu podijeliti na kratkoro\'e8ne i dugoro\'e8ne}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657 , a navedeni su u tablici 2 [5}{
\f1\lang1050\langfe1050\langnp1050\insrsid3959624 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid15955782 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid5505737 {\f1\lang1050\langfe1050\langnp1050\insrsid15955782 Od naj}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 va\'9enijih kratkoro\'e8nih maj\'e8inih}{
\f1\lang1050\langfe1050\langnp1050\insrsid15955782  rizika spominju se nastanak plu\'e6nog edema (kod kombinacije KS s tokoliticima iz skupine }{\f50\lang1050\langfe1050\langnp1050\insrsid15955782 \'e2}{
\f1\lang1050\langfe1050\super\langnp1050\insrsid15955782 2 }{\f1\lang1050\langfe1050\langnp1050\insrsid15955782 agonista)}{\f1\lang1050\langfe1050\langnp1050\insrsid12997436 , }{\f1\lang1050\langfe1050\langnp1050\insrsid1932972 
nastanak infekcije majke i ploda kod}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737\charrsid5505737  }{\f1\lang1050\langfe1050\langnp1050\insrsid5505737\charrsid3886103 prijevremenog prsnu\'e6a plodovih ovoja}{
\f1\lang1050\langfe1050\langnp1050\insrsid1932972  }{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 (PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 )}{\f1\lang1050\langfe1050\langnp1050\insrsid1932972  te pote\'9ako\'e6
e u dijagnostici i kontroli \'9ae\'e6erne bolesti tip I i gestacijskog dijabetesa}{\f1\lang1050\langfe1050\langnp1050\insrsid11033223 ,}{\f1\lang1050\langfe1050\langnp1050\insrsid1932972 
 jer antenatalno primjenjeni KS zbog antiinzulinskog djelovanja izazivaju prolaznu hiperglikemiju.}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737\charrsid5505737  }{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 Ozbiljniji dugoro\'e8ni maj\'e8in}{
\f1\lang1050\langfe1050\langnp1050\insrsid5505737 i rizici nakon jednokratne primjene KS nisu zabilje\'9eeni}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [5}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid5505737 .
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 Jo\'9a je uvijek sporna upotreba KS}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167  u svrhu pobolj\'9aanja novoro\'f0ena\'e8kog pobola i smrtnosti}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  kod}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737  }{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 a.

\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8732336 {\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 Meta \endash  analiza Hardinga i sur. (analiziraju\'e6i 15 studija u kojima je bilo}{
\f1\lang1050\langfe1050\langnp1050\insrsid16143092  uklju\'e8eno > 1400 trudno\'e6a s PPPOa}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 ) pokazuje da primjena KS pozit}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 ivno utije
\'e8e na novoro\'f0ena\'e8ki}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737  ishod i}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167  smanjenje u\'e8estalosti}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336  RDSa, IKK}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 ,}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 nekrotiziraju\'e6eg enterokolitisa (}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 NE}{
\f1\lang1050\langfe1050\langnp1050\insrsid5505737 )}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  i}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167  pernatalne smrtnosti}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  }{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 (}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 PM}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 )}{
\f1\lang1050\langfe1050\langnp1050\insrsid16143092  kod PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 a, bez obzira na vremensku duljinu trajanja prsnu\'e6a ovoja (}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 
RR 0.56; 0.47; 0.21; 0.68). Nisu}{\f1\lang1050\langfe1050\langnp1050\insrsid11033223  primje\'e6eni statisti\'e8ki zna\'e8ajno}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  pov}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 e\'e6
ani rizici nastanka infekcije majke (}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 RR 0.86; CI [0.61 \endash  1.20]}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 )}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  niti novoro\'f0en\'e8eta (RR 1.05; CI [0.66 \endash  1.68])}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [16}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid3886103 {\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 I u prospektivnoj ne}{\f1\lang1050\langfe1050\langnp1050\insrsid10495697 r}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 andomiziranoj}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336  studiji}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 ,}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  Vermilliona i }{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 sur. jednokratne doze KS kod PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 a ni}{
\f1\lang1050\langfe1050\langnp1050\insrsid7486167 su povezane s ve\'e6om u\'e8estalosti}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103  neonatalnih i maj\'e8inih infekcija, ali vi\'9a}{
\f1\lang1050\langfe1050\langnp1050\insrsid16143092 ekratne tjedne doze KS kod PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 a statisti\'e8ki zna\'e8ajno utije\'e8u na pove\'e6anje}{
\f1\lang1050\langfe1050\langnp1050\insrsid7486167  u\'e8estalosti novoro\'f0ena\'e8ke}{\f1\lang1050\langfe1050\langnp1050\insrsid5505737  sepse (p < 0.001), korioamnionitisa (p = 0.004}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 
) i }{\f1\lang1050\langfe1050\langnp1050\insrsid5505737 endometritisa majke (p = 0.004}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 )}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [17}{
\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid3886103 . }{\f1\lang1050\langfe1050\langnp1050\insrsid3886103 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid7364501 KS koji se danas koriste za prevenciju RDSa ( }{\f1\lang1050\langfe1050\langnp1050\insrsid7364501\charrsid7364501 deks}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid7364501 
ametazon i betametazon) uzrokuju privremeno (do 72 sata nakon primjene) smanjennje varijabilnosti fetalne sr\'e8ane akcije (sni\'9eeni undulatorni i silentni CTG zapis) kao i smanjenje}{\f1\lang1050\langfe1050\langnp1050\insrsid7364501  u\'e8estalosti}{
\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid7364501  fetalnih pokreta. Poznavanjem ovog nerazja\'9anjenog fenomena sprije\'e8ava se nepotrebna medicinska intervencija u smislu neposredne fetalne ugro\'9eenosti}{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [18}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid7364501 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid7364501 {\f1\lang1050\langfe1050\langnp1050\insrsid7364501 Od neonatalnih kratkoro\'e8nih rizika spominju se}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167  pove\'e6ana u\'e8
estalost novoro\'f0ena\'e8ke}{\f1\lang1050\langfe1050\langnp1050\insrsid7364501  sepse zbog protuupalnog i imunosupresivnog djelovanja KS te supresija rada nadbubre\'9ene \'9elijede (jatrogeno izazvana sekundarna adrenalna insuficijencija}{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657 ) [5}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid7364501 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid1522963 {\f1\lang1050\langfe1050\langnp1050\insrsid1522963\charrsid1522963 U nerandomizira}{\f1\lang1050\langfe1050\langnp1050\insrsid3959624 noj prospektivnoj studiji }{
\f1\lang1050\langfe1050\langnp1050\insrsid1522963\charrsid1522963 Dri}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 ula i sur. u\'e8estalost novoro\'f0ena\'e8ke}{\f1\lang1050\langfe1050\langnp1050\insrsid1522963\charrsid1522963  sepse prijevremeno ro
\'f0ene djece, nije bila statisti\'e8ki zna\'e8ajno povi\'9aena kod novoro\'f0en\'e8adi \'e8ije su majke primile jednokratne}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 ,}{\f1\lang1050\langfe1050\langnp1050\insrsid1522963\charrsid1522963  ali i vi
\'9aekratne doze KS u usporedbi s novoro\'f0en\'e8adi \'e8ije majke nisu antenetelno dobivale KS u svrhu prevencije RDSa}{\f1\lang1050\langfe1050\langnp1050\insrsid1522963  (}{\f1\lang1050\langfe1050\langnp1050\insrsid1522963\charrsid1522963 
3.9% kod jednokratne doze KS; 4.9% kod vi\'9aekratnih doza KS te 5 % kod novoro\'f0en\'e8adi \'e8ije majke nisu dobivale KS)}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [19}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid1522963\charrsid1522963 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid3886103 {\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid7364501 Nekoliko studija povezuje antenatalnu primjenu KS sa smanjenjem tjelesne te\'9e
ine i opsega glavice u perinatalnom razdoblju . Postoji sumnja da KS vi\'9ae utje\'e8u na rast i razvoj neuralnog tkiva nego na smanjenje tjelesnog rasta ploda. Me\'f0utim isti autori nisu na\'9ali statisti\'e8ku zna\'e8
aju razliku u tjelesnom rastu i opsegu glavice u dojena\'e8koj dobi, izme\'f0u dojan\'e8adi \'e8ije su majke dobivale KS u trudno\'e6i i onih koje to nisu}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [20}{
\f1\lang1050\langfe1050\langnp1050\insrsid9852290 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid7364501 .   
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid986598 {\f1\lang1050\langfe1050\langnp1050\insrsid7364501\charrsid986598 Post mort}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 em obdukcijskom analizom mozga}{
\f1\lang1050\langfe1050\langnp1050\insrsid7364501\charrsid986598  umrlih fetusa \'e8ije su majke antenatalno primale KS, Murphy i sur. nisu dokazali da p}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid986598 ojedin}{
\f1\lang1050\langfe1050\langnp1050\insrsid7364501\charrsid986598 a\'e8ne}{\f1\lang1050\langfe1050\langnp1050\insrsid986598  ali}{\f1\lang1050\langfe1050\langnp1050\insrsid7364501\charrsid986598  i vi\'9aestruke doze KS statisti\'e8ki zna\'e8ajno utije\'e8
u }{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid986598 na}{\f1\lang1050\langfe1050\langnp1050\insrsid986598\charrsid986598  smanjenje}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid986598  rast}{
\f1\lang1050\langfe1050\langnp1050\insrsid986598\charrsid986598 a fetalnog mo\'9edanog tkiva}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [21}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid986598\charrsid986598 .}{\f1\lang1050\langfe1050\langnp1050\insrsid3886103\charrsid986598   }{\f1\lang1050\langfe1050\langnp1050\insrsid986598\charrsid986598 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid16147889 {\f1\lang1050\langfe1050\langnp1050\insrsid16147889 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963 Jednom od najznamenitijih studija u modernoj opst}{\f1\lang1050\langfe1050\langnp1050\insrsid16147889 etri\'e8koj povijesti, prije vi\'9ae od 30 godina}{
\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963 , Liggins i Howie su dokazali da antenatalna primjena KS poma\'9ee u sprje\'e8avanju RDSa prijevreme}{\f1\lang1050\langfe1050\langnp1050\insrsid16324850 no ro\'f0ene djece. KS}{
\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963  s}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 u smanjili novoro\'f0ena\'e8ki pobol}{\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963  ako se dijete rodilo izme
\'f0u  24 sata i  tjedan dana od davanja KS profilakse (3.6% kod davanja KS naprema 33.3% placebo; p= 0.03), me\'f0utim statisti\'e8k}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 e zna\'e8ajne razlike u novoro\'f0ena\'e8kom}{
\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963  ishodu nije bilo ako je porod uslijedio nakon tijedan dana (2.2% kod davanja KS naprema 9.4% placebo; p > 0.05)}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290  [2]}{
\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963 . }{\f1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid9852290 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid4287157 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16650781 Studi}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12335406 ja CGAST (Collaborative Group on}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16650781  Antenatal Steroid Therapy) tako\'f0er je pokazala da antenatalno primjenjena jedna doza KS u usporedbi}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7486167  s placebom smanjuje u\'e8estalost}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16650781  RDSa ako porod nastupi izme\'f0u 24 sata i tjedan dana od davanja KS profilakse ( 9.3% kod KS naprema 20.1% kod placeba). Ako je porod uslijedio nakon tjedan dana, KS nisu u zna\'e8
ajnoj mjeri smanjili u\'e8estalost RDSa (6.0% kod KS naprema 10.5% kod placeba)}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4619657  [22}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290 ]}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16650781 .}
{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4287157 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid20266 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12335406 Zbog spoznaje o smanjenju u\'e8inkovitosti KS ako porod nastupi nakon tjedan dana od njihovog davanja}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid6520468 , mnogo porodni\'e8ara podupire tezu da su potrebne vi\'9aekratne, tjedne doze KS}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7486167  u svrhu pobolj\'9aanja novoro\'f0ena\'e8kog}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid6520468  ishoda}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid20266 ,}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid20266\charrsid20266  }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid20266 
iako ne postoje objektivni dokazi o njihovoj u\'e8inkovitosti i mogu\'e6im kratkoro\'e8nim i dugoro\'e8nim potencijalnim rizicima.
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid6520468 {\f1\lang1050\langfe1050\langnp1050\insrsid20266\charrsid20266 U 279 medicinskih centara u Velikoj Britaniji, oko 75% opstetri\'e8ara rutinski primjenjuje vi\'9a
estruke doze KS, naj\'e8e\'9a\'e6e zbog prijete\'e6eg prij}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 evremenog poroda (81.8%) i PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid20266\charrsid20266 a (84.2%)}{
\f1\lang1050\langfe1050\langnp1050\insrsid7486167  [23]}{\f1\lang1050\langfe1050\langnp1050\insrsid20266\charrsid20266 . U Australiji postotak porodni\'e8ara koji rutinski primjnjuju vi\'9aestruke doze je i do 85%}{
\f1\lang1050\langfe1050\langnp1050\insrsid7486167  [}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657 24}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid20266\charrsid20266 .}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid6520468\charrsid20266    }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid12335406\charrsid20266   
\par }{\f1\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid7739851 
\par 
\par }{\f1\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid8812958 
\par 
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\par }{\f1\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid8284272\charrsid20266 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid4287157 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid5779896\charrsid5779896 Pozitivni u\'e8inci i rizici vi\'9aekratnih antenatalnih doza kortikostroida }{
\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4876161\charrsid5779896 
\par }{\b\cf1\lang1050\langfe1050\langnp1050\insrsid4287157\charrsid10567963 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3299890 Do danas ne postoje rezultati, dobro dizajnirane dvostruk}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8284272 
o slijepe randomizirane studije}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3299890  o prednostima}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440  i rizicima vi\'9aekratne primjene}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3299890 
 u odnosu na jed}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440 no}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3299890 kratnu }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440 antenatalnu }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3299890 primjenu }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440 KS.}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8284272 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10823877 Najzna\'e8ajnija pretpostavljena prednost vi\'9aekratne}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4611767 
 (profilakti\'e8ke}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10823877 ) antenatalne primjene KS u odnosu na jednakratnu primjenu je }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8284272 smanjenje incidencije RDSa i IKK}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7082082 , jer u\'e8inkovitost KS nakon primjene jednokratne doze prestaje nakon  7\endash  10 dana }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4619657 [25}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10823877 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13974474 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8284272 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 Vi\'9aekratne antenatalne doze KS}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272\charrsid8284272  }{\f1\lang1050\langfe1050\langnp1050\insrsid8284272\charrsid4611767 ne utije\'e8u}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  negativno na dugotrajni neuropsiholo\'9aki razvoj ( inteligenciju, pona\'9aanje, uspje\'9anost u u\'e8enju i radu, promjer glavice ) kod djece \'9akolske dobi \'e8
ije su majke antenatalno dobivale KS}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [26}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 . \'8atovi\'9a
e antenatalni KS dugotrajno pobolj\'9aavaju kognitivne funkcije djece veoma niske tjelesne te\'9eine (VNTT}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767  }{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 
< 1500 g.) i antenatalno ultrazvu\'e8no di}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767 j}{\f1\lang1050\langfe1050\langnp1050\insrsid10633214 agnosticiranih cerebralnih}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  malformacija
}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767  (}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 CI [1.8 \endash  15.6]; p =0.016). KS ne pobolj\'9aavaju statisti\'e8ki zna\'e8ajno kognitivne funkcije}{
\f1\lang1050\langfe1050\langnp1050\insrsid8732336  djece}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  VNTT bez pridru\'9e}{\f1\lang1050\langfe1050\langnp1050\insrsid10633214 enih cerebralnih}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  malformacija}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [27}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 . Doyle i sur. su retospektiv}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 nom kohortnom studijom}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 
, opovrgnuli postojanje pretpostavljenih dugotrajnih kognitivnih rizika antenatalnih KS. U populaciji 14 godi\'9anjaka nisu na\'9a}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 li nikakvu razliku}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  u rastu, kognitivnim i plu\'e6nim funkcijama djece \'e8ije su majke antenatalno primale KS}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092  [28]}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 , ali su zaklju\'e8ili}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336  na temelju druge studije }{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 
da antenatalna primjena}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336  KS statisti\'e8ki zna\'e8ajno utije\'e8e}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  na povi\'9aejne sistoli\'e8kog i dijastoli\'e8kog tl}{
\f1\lang1050\langfe1050\langnp1050\insrsid8732336 aka te}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  da bi mogla biti jedan od uzroka hipertenzije u \'9akolskoj i adolescentnoj dobi}{
\f1\lang1050\langfe1050\langnp1050\insrsid16143092  [}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657 29}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid4611767 {\f1\lang1050\langfe1050\langnp1050\insrsid1075182 Opisan je i slu\'e8aj ku\'9aingoidnog sindroma kod novoro\'f0en\'e8eta \'e8ija je majka tijekom trudno\'e6
e primila sedam profilakti\'e8kih doza KS}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [30}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid1075182 . }{
\f1\lang1050\langfe1050\langnp1050\insrsid1075182\charrsid4611767 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 French i sur. su svojom re}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 trospektivnom kohortnom studjom}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 ,}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767  upozorili da vi\'9aekra}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 t}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 
ne antenatalne doze KS (> 3 doze) negativno utije\'e8u na psihosocijalni razvoj djece pred\'9akolske dobi. U skupini djece \'e8ije su majke antenatalno primale vi\'9ae od 3 doze KS, primje\'e6en je statisti\'e8ki zna\'e8ajo pove\'e6
ana incidencija psihosocijalnih poreme\'e6aja (hiperreaktivnost,}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092  }{\f1\lang1050\langfe1050\langnp1050\insrsid1075182 smanjen}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092 
 kvocijent inteligencije (IQ)}{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 )}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [31}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767 .}{\f1\lang1050\langfe1050\langnp1050\insrsid1075182 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8812958 {\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid4611767   }{\f1\lang1050\langfe1050\langnp1050\insrsid4611767\charrsid8812958 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8812958 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440 Dosada\'9anje studije usporedbe}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7082082  prednosti i potencijalnih rizika }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440 vi\'9a
ekratne i jednokratne prim}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13974474 jene KS prikazane su u tablici 3}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8213440 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8213440 {\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440 Meta-analizom 8 prospektivnih i retrospektivnih humanih studija}{
\f1\lang1050\langfe1050\langnp1050\insrsid7486167 , koje su uspore\'f0ivale  maj\'e8in}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440 e}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167  i novoro\'f0ena\'e8ke}{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  pozitivne u\'e8inke}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440  i rizike}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440 , }{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440 izme\'f0u antenatalno}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  primjene}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440 nih}{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  vi\'9aekratnih}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440  }{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440 
i jednokratnih doza KS, Aghajafari i sur. su iznjeli zaklju\'e8ke da vi\'9aekratne doze KS pozitivno i statisti\'e8ki zna\'e8ajno }{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 utije\'e8u na smanjenje u\'e8estalosti}{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  RDSa (OR 0.79; CI [0.64 - 0.98}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440 ]), }{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440 ali da pove\'e8ava}{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440 ju}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167  iu\'e8estalost}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  endometritisa (OR 3.42; CI [1.92 to 6.11]}{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440  u odnosu na jednokratnu dozu KS}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 . Ostali promatrani novoro\'f0ena\'e8ki}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  i maj\'e8
inski rizici i }{\f1\lang1050\langfe1050\langnp1050\insrsid8213440 prednosti izme\'f0u ovih dviju skupina}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440  nisu se statsti\'e8ki zna\'e8ajno razlikovali}{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [24}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440 .}{\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid8213440 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid1007121 {\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 Ali}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121  u jednoj}{
\f1\lang1050\langfe1050\langnp1050\insrsid8284272  od }{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 nedavno zavr\'9aenih, dvostruko slijepo }{\f1\lang1050\langfe1050\langnp1050\insrsid14317205 randomiziranoj prospektivnoj}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121  }{\f1\lang1050\langfe1050\langnp1050\insrsid14317205 studiji}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121  o usporedbi jednokratne i vi\'9a
ekratne (tjedne) antenatalne primjene KS, Guinna i sur. nije potvrdila opravdanost tjednog profilakti\'e8kog dava}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 nja KS u svrhu pobolj\'9aanja novoro\'f0ena\'e8kog pobola i smrtnosti}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 .      }{\f1\lang1050\langfe1050\langnp1050\insrsid14317205 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 Trudnicama izme\'f0u 24 \endash  34 tjedna trudno\'e6e kod kojih je postojala opasnost od prijevremenog poroda data je jedna doza KS}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205  (
}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 betametazom }{\f1\lang1050\langfe1050\langnp1050\insrsid7082082 2x12 mg im.}{\f1\lang1050\langfe1050\langnp1050\insrsid16143092  ili deks}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 ametazon }{\f1\lang1050\langfe1050\langnp1050\insrsid7082082 4x6 mg im. unutar 24 sata}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 ). One koje nisu rodile u slijede
\'e6eh 7 dana su bile kandidatkinje za ulazak u studiju. Metodom slu\'e8ajnog odabira randomizirane su ili u skupinu koja je dobivala tjednu (profilakti\'e8ku) dozu KS i}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205 li su tjedno dobivale placebo (}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 umjesto KS dobivale su farmakolo\'9aki ne\'9akodljivu i neu\'e8inkovitu tvar, apliciranu i}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 ntra}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 m}{\f1\lang1050\langfe1050\langnp1050\insrsid8732336 uskularno}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121  na isti}{
\f1\lang1050\langfe1050\langnp1050\insrsid14317205  na\'e8in kao i KS}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 ), do poroda ili navr\'9aenog 34 tjedna trudno\'e6e. Primarni cilj studije bila je usporedba sl}{
\f1\lang1050\langfe1050\langnp1050\insrsid8284272 o\'9e}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 enog novoro\'f0ena\'e8kog}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272  ishoda }{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 izme\'f0u ove dvije skupine. S}{\f1\lang1050\langfe1050\langnp1050\insrsid7486167 lo\'9eeni novoro\'f0ena\'e8ki}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272  ishod}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121  je uklju\'e8ivao: III i IV stupanj RDSa, bronhopulmonalnu displa}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 ziju (BPD), III i IV stupanj IKK}{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 , periventrikularnu leukomalaciju (PVL), neonatalnu sepsu (NS), nekrotiziraju\'e6i enterokolit}{\f1\lang1050\langfe1050\langnp1050\insrsid10903338 is (NE) i perinatalnu smrtnost}{
\f1\lang1050\langfe1050\langnp1050\insrsid7486167  (PS}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 ). Tjedna primjena KS u odnosu na jednokratnu dozu KS nije statisti\'e8ki zna\'e8ajno smanjila u\'e8es}{
\f1\lang1050\langfe1050\langnp1050\insrsid10903338 talost slo\'9eenog novoro\'f0ena\'e8kog pobola i smrtnosti}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205  (}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 22.5}{
\f1\lang1050\langfe1050\langnp1050\insrsid14317205 %}{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121  kod profilakti\'e8ke prema 28}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205 % }{
\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 kod jednokratne primjene KS, RR 0.8; CI [ 0.59 - 1.10]).}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205  Ali vi\'9aekratne tjedne doze KS su statisti\'e8ki zna\'e8ajno smanji}{
\f1\lang1050\langfe1050\langnp1050\insrsid3148266 le}{\f1\lang1050\langfe1050\langnp1050\insrsid10903338  novoro\'f0ena\'e8ki pobol i u\'e8estalost}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205  RDSa kod djece ro\'f0ene prije 28 tjedna trudno\'e6e}{
\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [32}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205 . }{\f1\lang1050\langfe1050\langnp1050\insrsid1007121\charrsid1007121 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid14317205 {\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 Dirnberger i sur. tako\'f0er su uspore\'f0ivali u\'e8inkovitost vi\'9a
ekratne i jednokratne antenatalne primjene KS izme\'f0u 27 \endash  32 tjedna}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272  gestacije u jednoplodnim}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205  i izme\'f0u 26 \endash 
 32 tjedna}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272  gestacije u vi\'9aeplodnim }{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 trudno\'e6ama. Vi\'9aekratne doze KS niti u jednoj skupini nisu smanjile broj novoro\'f0ena\'e8
kih kroni\'e8nih plu\'e6nih bolesti (KPB), u\'e8estalost RDSa, I}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 KK}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 , ranih infekcija, te\'9e
ih oblika retinopatija povezanih s prematuritetom niti duljinu hospitalizacije u odnosu na jednokratnu primjenu KS. Jedini pozitivni u\'e8inak vi\'9aestrukih doza KS je ubrzano pove\'e6anje tjelesne te\'9eine nakon ro\'f0enja ali samo u vi\'9a
eplodnim trudno\'e6ama}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [33}{\f1\lang1050\langfe1050\langnp1050\insrsid7868403 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid7868403 {\f1\lang1050\langfe1050\langnp1050\insrsid8284272 Retrospektivnom studijom,}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 
 Abassi i sur. su ustvrdili da vi}{\f1\lang1050\langfe1050\langnp1050\insrsid2242475 \'9aekratne doze KS (2 do 12 doza}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 ) u usporedbi s pojedina\'e8nom dozom KS statisti\'e8ki zna\'e8aj}{
\f1\lang1050\langfe1050\langnp1050\insrsid2242475 no utije\'e8u na prevenciju RDSa (}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 OR 0.44; }{\f1\lang1050\langfe1050\langnp1050\insrsid2242475 CI [ 0.25 \endash  0.79]; p = 0.005}{
\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 ) ali i uzrokuju smanjenje opseg gl}{\f1\lang1050\langfe1050\langnp1050\insrsid2242475 avice novoro\'f0en\'e8adi (p = 0.013}{
\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205 )}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [34}{\f1\lang1050\langfe1050\langnp1050\insrsid7868403 ].}{\f1\lang1050\langfe1050\langnp1050\insrsid14317205\charrsid14317205  }{
\f1\lang1050\langfe1050\langnp1050\insrsid8213440\charrsid7868403 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid13979338 {\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 Reultati Sjeverno ameri\'e8ke retrospektivne TRH studije ne opravdavaju upotrebu vi\'9aekratnih 
antenatalnih doza KS u svrhu prevencije RDSa, \'9atovi\'9ae prema njihovim rezultatima vi\'9aekratne doze KS su poveza}{\f1\lang1050\langfe1050\langnp1050\insrsid3148266 ne s lo\'9aijim novoro\'f0ena\'e8kim }{
\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 ishodom u smislu p}{\f1\lang1050\langfe1050\langnp1050\insrsid10903338 ovi\'9aenja novoro\'f0ena\'e8ke smrtnosti}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 
, zastoja u rastu ploda i supresije rada fetalne nadbubre\'9ene \'9elijezde}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [35}{\f1\lang1050\langfe1050\langnp1050\insrsid7868403 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 
. 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid882483 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180 U retrospektivnoj studiji Jazayeria i sur., t}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483 
jedna profilkti\'e8ka antenatalna upotreba KS ne pridonosi statisti\'e8ki zna\'e8ajno smanjenju }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10903338 slo\'9eenog }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3148266 no}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10903338 voro\'f0ena\'e8kog pobola}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483  (}{\f1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483 OR 1.3; CI [1.02-1.8])}{
\f1\lang1050\langfe1050\langnp1050\insrsid6780980  }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483 niti ne }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10903338 utije\'e8e na smanjenje u\'e8estalosti}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483  RDSa}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10903338  }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483 (}{
\f1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483 OR 1.3; CI [1.04-1.7])}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657 [36}{\f1\lang1050\langfe1050\langnp1050\insrsid7868403 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid882483\charrsid882483 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid11752223 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11752223\charrsid11752223 Elimian i sur. su iznjeli rezultate da vi\'9aekratne antenatalne doze KS pozitivno }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid10903338 djeluju na smanjenje u\'e8estalosti}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11752223\charrsid11752223  RDS (}{\f1\lang1050\langfe1050\langnp1050\insrsid11752223\charrsid11752223 
p<0.001) i smanjuju postnatalnu upotrebu kisika (p=0.02) u odnosu na jednokratnu dozu KS}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [37}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid11752223 .

\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid13979338 {\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 Murphy i sur. su uspore\'f0ivali ishode izme\'f0u dva postoje\'e6
a pristupa prevencije RDSa u blizana\'e8koj trudno\'e6i. U ovoj retrospektivnoj kohortnoj studiji }{\f1\lang1050\langfe1050\langnp1050\insrsid8073250 u koju je bilo uklju\'e8}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 
eno 1038 blizana\'e8kih trudno\'e6a uspore\'f0ivao se ishod izme\'f0u}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272  profilakti\'e8ke prevencije (}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 rutinsko davanje KS svaka 2
 tjedna izme\'f0u 24 \endash  32 tjedana }{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 trudno\'e6e) i hitne prevencije (}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 davanje samo jedn}{
\f1\lang1050\langfe1050\langnp1050\insrsid8284272 okratne}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338  doze KS ako su postojali znakovi prijete\'e6eg prijevremenog }{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 
poroda i opasnost da do poroda }{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 do\'f0}{\f1\lang1050\langfe1050\langnp1050\insrsid6780980 e u slijede\'e6ih 24}{\f1\lang1050\langfe1050\langnp1050\insrsid7082082  sati do }{
\f1\lang1050\langfe1050\langnp1050\insrsid13979338 7 dana}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 ).
\par Profilakti\'e8ka primjena KS nije se pokazala opravdanim terapijskim postupkom jer nije u odnosu na hitnu terapiju dovela do statisti\'e8ki zna\'e8ajnog smanjenja RDSa ( OR 0.7; CI [0.2 \endash  2.0]. Izbjegavanjem profilakti\'e8
ke primjene KS, smanjuje se nepotrebno davanje KS te potencijalno \'9atetni u\'e8inci vi\'9aekratne primjene KS}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [38}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 .   
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid6648823 U}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338  retrospektivnoj studiji Pratta i sur., vi\'9aekratne doze KS povezane su s manjim iskori\'9a
tavanjem kisika u fetalnim tkivima. Manja iskori\'9atenost kisika mogla bi biti uzrokom smanjenog }{\f1\lang1050\langfe1050\langnp1050\insrsid10903338 tjelesnog rasta, rasta mozga i }{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 
dugotrajnijih razvojnih poreme\'e6aja}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [39}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180 ]}{\f1\lang1050\langfe1050\langnp1050\insrsid13979338\charrsid13979338 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid13979338 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid7082082\charrsid13979338 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8666489 {\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 Caughey i Parer ,su meta \endash  analizom retrospektivnih i prospektivnih studija o u\'e8
estalosti primjene KS i matemat\'e8kim modelom o pet rali\'e8itih pristupa prevenciji RDSa ( 1. jednokratna doza KS; 2. vi\'9aekratne tjedne doze KS; 3. vi\'9aekratne doze KS svaki drugi tjedan; 4. dvije doze KS u razmaku od 2 tjedna; 5. vi\'9a
ekratne doze KS svaki drugi tjedan ali ne vi\'9ae od 3 doze > 30 tjedna ili ne vi\'9ae od 2 doze > 32 tjedna) kod prijete\'e6eg prijevremenog poroda}{\f1\lang1050\langfe1050\langnp1050\insrsid477443  izme\'f0u}{
\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489  24 \endash  34 tjedna trudno\'e6e, iznjeli mi\'9aljenje da \'e6e najbolji omjer izme\'f0u prevencije RDSa i pove\'e6anja}{\f1\lang1050\langfe1050\langnp1050\insrsid10903338  ukupnoe novoro
\'f0na\'e8ke smrtnosti}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489     
\par biti postignut modelom kod kojeg se daju maksimalno dvije doze KS u razmaku od 2 tjedna}{\f1\lang1050\langfe1050\langnp1050\insrsid4619657  [40}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180 ]}{
\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 .
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13974474 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16583465 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8284272 
\par 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 Zaklju\'e8ci
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8666489 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8666489 {\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 Jednokratna doza KS smanjuje p}{\f1\lang1050\langfe1050\langnp1050\insrsid10903338 erinatalnu smrtnost}
{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 , RDS i IKK}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 . Podaci o vi\'9a
ekratnoj primjeni KS se uglavnom temelje na retrospektivnim i nerandomiziranim prospektivnim studijama. Neke od tih studija pretpostavljaju da vi\'9aekra}{\f1\lang1050\langfe1050\langnp1050\insrsid10903338 tne doze KS smanjuju u\'e8estalost}{
\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489  }{\f1\lang1050\langfe1050\langnp1050\insrsid10903338 RDSa, ali pove\'e6avaju u\'e8estalost}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489  infekcija kod majke i novoro
\'f0en\'e8eta, supresiju rada nadbubre\'9ene \'9elijezde majke, fetusa i novoro\'f0en\'e8eta, smanjenje fetalnog i novoro\'f0ena\'e8kog tjelesnog rasta kao i rasta i razvoja fetalnog mo\'9edanog tkiva i p}{
\f1\lang1050\langfe1050\langnp1050\insrsid10903338 ove\'e6avaju preinatalnu smrtnost}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 .
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid11300180 Zbog toga se}{\f1\lang1050\langfe1050\langnp1050\insrsid477443  danas}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180  }{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 p}{
\f1\lang1050\langfe1050\langnp1050\insrsid11300180 reporu\'e8a}{\f1\lang1050\langfe1050\langnp1050\insrsid4403520  da}{\f1\lang1050\langfe1050\langnp1050\insrsid477443  se}{\f1\lang1050\langfe1050\langnp1050\insrsid4403520  svak}{
\f1\lang1050\langfe1050\langnp1050\insrsid477443 oj}{\f1\lang1050\langfe1050\langnp1050\insrsid4403520  trudnici}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489  izme\'f0u 24 i 34 tje}{\f1\lang1050\langfe1050\langnp1050\insrsid477443 
dna trudno\'e6e, kod koje postoji}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489  rizik prijevremenog poroda}{\f1\lang1050\langfe1050\langnp1050\insrsid3940359  }{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 
u slijede\'e6ih tjedan dana}{\f1\lang1050\langfe1050\langnp1050\insrsid3940359 , radi postizanja plu\'e6e zrelosti i prevencije novoro\'f0ena\'e8kog RDSa, primjeni samo jedna}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272  doza KS (deksametazona a 2}{
\f1\lang1050\langfe1050\langnp1050\insrsid3940359 x}{\f1\lang1050\langfe1050\langnp1050\insrsid8284272 12}{\f1\lang1050\langfe1050\langnp1050\insrsid3940359  mg im. }{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 ili betametazona}{
\f1\lang1050\langfe1050\langnp1050\insrsid8284272  a}{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489  }{\f1\lang1050\langfe1050\langnp1050\insrsid3940359 2x12 mg im. unutar 24 sata}{
\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 )}{\f1\lang1050\langfe1050\langnp1050\insrsid3940359 .
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid8666489 Zbog nepotpunih podataka o koristima i \'9atetnostima vi\'9aekratnih doza KS, vi\'9aekratne doze KS se ne bi trebale primjenjivati rutinski. Primjenivanje vi\'9aekratnih doza KS je s
trogo rezervirana samo za trudnice koje \'e6e biti uklju\'e8ene u randomizirana prospektivna istra\'9eivanja.    
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8666489\charrsid10567963 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 
\par 
\par 
\par 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056 
\par 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137 
\par 
\par 
\par 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8812958 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3811791 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520\charrsid7878137 Literatura}{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid7878137 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid3899056 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520\charrsid7878137 1. Marde\'9ai\'e6 D. i sur. Novoro\'f0en\'e8e. U. Pedijatrija:\'8akolska knjiga Zagreb: 2000.;}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid2102669  pp }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520\charrsid7878137 328-333}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 
\par 2.}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137  Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972;50:515-525. 

\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 3.}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137  Bolt RJ, van Weissenbruch MM, Lafeber HN, Delemarre-van de Waal HA. G
lucocorticoids and lung development in the fetus and preterm in}{\f1\lang1050\langfe1050\langnp1050\insrsid15549543 fant. Pediatr Pulmonol. 2001}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 ;32(1):76-91.}{
\f1\lang1050\langfe1050\langnp1050\insrsid3899056 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid1335977 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977\charrsid1335977 4.}{\f1\cf1\insrsid1335977\charrsid1335977 
 Baud O, Zupan V, Lacaze-Masmonteil T, et al. The relationships between prenatal management, the cause of delivery and neonatal outcome in a large cohort of very preterm singletons. Br J Obstet Gynaecol 2000;107:877-}{\f1\cf1\insrsid1335977 8}{
\f1\cf1\insrsid1335977\charrsid1335977 84}{\f1\cf1\insrsid1335977 .}{\f1\cf1\insrsid1335977\charrsid1335977 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\tx1875\faauto\rin0\lin0\itap0\pararsid1335977 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 5}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 .}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137  National Institute of Child Health and Human Development Office of Medical Applications of Research N. Effect of corticosteroids 
for fetal maturation on preinatal outcomes. Vol.95-3784:NIH Publication, 1994. }{\f1\cf1\insrsid3899056\charrsid1335977 
\par }\pard \ql \li0\ri0\sl360\slmult1\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0\pararsid3899056 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 6}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 .}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137  Collaborative Group on Antenatal Steroid Therapy: Effect of antenatal dexamethasone administration on the prevention of respiratory distress syndrome. Am J Obstet Gynecol 1981;141:276

\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid1990261 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 7}{\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid1990261\charrsid7878137  Meadow WL, Bell A, Sunstein CR. Statistics, not memories: what was the standard of care for administering antenatal steroids to women in preterm labor between 1985 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9852290 {\f1\lang1050\langfe1050\langnp1050\insrsid1990261\charrsid7878137 and 2000? Obstet Gynecol. 2003;102(2):356-362.}{
\f1\lang1050\langfe1050\langnp1050\insrsid3899056\charrsid7878137 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid16012863 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 8}{\f1\lang1050\langfe1050\langnp1050\insrsid1990261\charrsid7878137 .}{
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 Moise AA, Wearden ME, Kozinetz CA, Gest AL, Weltry SE, Hansen TN. Antenatal steriods are associeted with less need for blood pressure support in extreme premature infants.Pediatrics 1995;95:845-850. 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid7878137 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 10}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid7878137  }{\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 
McEvoy C, Bowling S, Williamson K, Stewart M, Durand M. Functional residual capacity and passive compliance measurements after antenatal steroid therapy in preterm infants. Pediatr Pulmonol. 2001;31(6):425-430.}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 11}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137  }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 Dem
arini S, Dollberg S, Hoath SB, Ho M, Donovan EF. Effects of antenatal corticosteroids on blood pressure in very low birth weight infants during the first 24 hours of life. J Perinatol. 1999;19(6 Pt 1):419-425.
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\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137  Muller T, Nanan R, Dietl J. Effect of antenatal corticosteroid administration on Doppler flow velocity parameters in pregnancies with absent or reverse end-diastolic 
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\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 13}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid7878137  }{\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 
Potter SM, Dennedy MC, Morrison JJ. Corticosteroids and fetal vasculature: effects of hydrocortisone, dexamethasone and betamethasone on human umbilical artery.
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\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9852290 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 14}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137  Elimian A, Figueroa R, Spitzer AR, Ogburn PL, Wiencek V, Quirk JG. Antenatal corticosteroids: are incomplete courses beneficial? Obstet Gynecol. 2003;102(2):352-355.}{
\f1\lang1050\langfe1050\langnp1050\insrsid16012863 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 15}{\f1\lang1050\langfe1050\langnp1050\insrsid8812958 .}{\f1\lang1050\langfe1050\langnp1050\insrsid4592529 
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\f1\lang1050\langfe1050\langnp1050\insrsid8812958\charrsid7878137 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid16012863 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 16}{\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid7878137  }{\f1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 
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\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 17}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137  }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 Vermillion 
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\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9852290 {\f1\lang1050\langfe1050\langnp1050\insrsid1335977 19}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 
. Driul L, Furlan R, Macagno F, Pezzani I, Plaino L, Ianni A, Casarsa S, Zavarise D, Marchesoni D. Induction of fetal lung maturation in the prevention of hyaline 
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\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 20}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 
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\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 22}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 
 Collaborative Group on Antenatal Steroid Therapy.Effects of antenatal dexamethason administration in the infant:Long term follow-up.J Pediatr 1984;104:259
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 23}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 
 Brocklehurst P, Gates S, McKenzie-McHarg K, Alfirevic Z, Chamberlain G.\line Are we prescribing multiple courses of antenatal corticosteroids? A survey of practice in the UK}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid15549543 
. Br J Obstet Gynaecol. 1999}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 ;106(9):977-9.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 24}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 . Quinlivian JA, Evans SF, Dunlop SA, Beazley LD, Newnham JP.Use of corticosteriods by Australian obstetricians \endash 
 a srvey of clinical practice.Aust NZ Obstet Gynaecol. 1998;38:1-7.}{\f1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid7739851 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 25}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9852290\charrsid7878137 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137  Aghajafari F, Murphy K, Willan A, Ohlsson A, Amankwah K, Matthews S, 
\par Hannah M. Multiple courses of antenatal corticosteroids: a systematic review and 
\par meta-analysis. Am J Obstet Gynecol. 2001;185(5):1073-1080
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 26}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 
 Thorp JA, O'Connor M, Belden B, Etzenhouser J, Hoffman EL, Jones PG. Effects of phenobarbital and multiple-dose corticosteroids on developmental outcome at age 7 years. Obstet Gynecol. 2003;101(2):363-373.
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 27}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid7878137  }{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 
Arad I, Durkin MS, Hinton VJ, Kuhn L, Chiriboga C, Kuban K, Bellinger D. Long-term cognitive benefits of antenatal corticosteroids for prematurely born children with cranial ultrasound abnormalities. Am J Obstet Gynecol. 2002;186(4):818-825.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 28}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137  }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 Doyle LW, Ford GW, Rickards AL, Kelly EA, Davis NM, Callanan C, Olinsky A. Antenatal corticosteroids and outcome at 14 years of age in children with birth weight less than 1501 grams}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 . Pediatrics. 2000;106(1):E2.\line 29}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137  }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci (Lond). 2000;98(2):137-142.
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid1335977 30}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid7878137  }{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 
Bradley BS, Kumar SP, Mehta PN, Ezhuthachan SG. Neonatal cushingoid syndrome resulting from serial courses of antenatal betamethasone. Obstet Gynecol. 1994;83(5 Pt 2):869-872.}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid8812958 \line 3}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 1}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7878137  }{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 
French NP, Hagan R, Evans S, Godfrey M, Newnham J.\~The benefits of antenatal administration of corticosteroids to fetuses. Repeated antenatal corticosteroids: Behavior outcomes in a regional population of very preterm infants. Ped.Res.1997;42:3;405}{
\f1\insrsid7739851\charrsid7878137 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 32}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137  Guinn DA, Atkinson MW, Sullivan L, Lee M, MacGregor S,
 Parilla BV, 
\par Davies J, Hanlon-Lundberg K, Simpson L, Stone J, Wing D, Ogasawara K, 
\par Muraskas J. Single vs weekly courses of antenatal corticosteroids for women at risk 
\par of preterm delivery: A randomized controlled trial. JAMA. 2001;286(13):1581-1587.
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid7868403 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 33}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7739851\charrsid7878137 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid7868403\charrsid7878137  Dirnberger DR, Yoder BA, Gordon MC. Single versus repeated-course antenatal corticosteroids: outcomes in singleton and multiple-gestation pregnancies. Am J Perinatol. 2001;18(5):267-277.

\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 34}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7868403\charrsid7878137 . Abbasi S, Hirsch D, Davis J, Tolosa J, Stouffer N, Debbs R, Gerd
es JS. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol. 2000;182(5):1243-1249}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16012863\charrsid7878137 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid11300180 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 35}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7868403\charrsid7878137 .}{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137  Banks BA, Cnaan A, Morgan MA, Parer JT, Merrill JD, Ballard PL, Ballard RA. Multiple courses of an
tenatal corticosteroids and outcome of premature neonates. North American Thyrotropin-Releasing Hormone Study Group.Am J Obstet Gynecol. 1999;181(3):709-717.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 36}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 . Jazayeri A, Gavrila D, Sincich T.}{\f1\insrsid11300180\charrsid7878137  }{
\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 Repeated antenatal corticosteroid treatments. Do they reduce neonatal morbidity?J Reprod Med. 2001;46(9):788-790.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 37}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 
 Elimian A, Verma U, Visintainer P, Tejani N.Effectiveness of multidose antenatal steroids.Obstet Gynecol.2000;95(1):34-36.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 38}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137  Murphy DJ, 
Caukwell S, Joels LA, Wardle P. Cohort study of the neonatal outcome of twin pregnancies that were treated with prophylactic or rescue antenatal corticosteroids. Am J Obstet Gynecol. 2002;187(2):483-488.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 39}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 . Pratt L, Waschbusch L, Ladd W, Gangnon R, Hendri
cks SK.Multiple vs. single betamethasone therapy. Neonatal and maternal effects.J Reprod Med. 1999;44(3):257-264.
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1335977 40}{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 .}{\f1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid7878137 
 Caughey AB, Parer JT. ecommendations for repeat courses of antenatal corticosteroids: a decision analysis. Am J Obstet Gynecol. 2002;186(6):1221-1226.
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8073250 {\f1\lang1050\langfe1050\langnp1050\insrsid11300180\charrsid8666489 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid7868403 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid7868403\charrsid4357107 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid3899056 {\f1\lang1050\langfe1050\langnp1050\insrsid1990261\charrsid3899056 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid4403520\charrsid10567963 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599 
\par 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13456394 
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\par 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid2102669\charrsid9127599 Indikacije i kontraindikacije za antenatalnu primjenu kortikosteroida}{\f1\lang1050\langfe1050\langnp1050\insrsid2102669 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid1795582 
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\par }\trowd \irow0\irowband0\ts17\trgaph108\trrh539\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
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\f1\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 INDIKACIJE ZA ANTENATALNU
\par PRIMJENU KS}{\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 \cell }{\f1\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 KONTRAINDIKACIJE ZA ANTENATALNU PRIMJENU KS\cell }\pard\plain 
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\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposy3184\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4644\clshdrawnil \cellx4536\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4644\clshdrawnil \cellx9180\row }\trowd \irow1\irowband1\lastrow \ts17\trgaph108\trrh3106\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposy3184\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4644\clshdrawnil \cellx4536\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4644\clshdrawnil \cellx9180\pard\plain \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid12800265\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {
\f1\fs22\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 
\par }\pard\plain \s18\ql \li0\ri720\sb100\sa100\sl360\slmult1\widctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\aspalpha\aspnum\faauto\adjustright\rin720\lin0\pararsid8284272\yts17 
\f2\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 1.  pravi i prijete\'e6i prijevremeni porod}{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid8284272 
                   
\par     (prije navr\'9aenih 34 tjedana truno\'e6e) }{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 
\par }\pard \s18\ql \li0\ri720\sb100\sa100\sl360\slmult1\widctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\aspalpha\aspnum\faauto\adjustright\rin720\lin0\pararsid12800265\yts17 {
\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 2. antepartalno krvarenje
\par }{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid15549543 3. PPPO}{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 
\par 4. svako drugo stajne koje zahtijeva prijevremeno dovr\'9aenje trudno\'e6e
\par }\pard\plain \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid12800265\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {
\f1\fs22\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 \cell }\pard\plain \s18\ql \li0\ri720\sb100\sa100\sl360\slmult1
\widctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\aspalpha\aspnum\faauto\adjustright\rin720\lin0\pararsid12800265\yts17 \f2\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {
\f1\fs22\ul\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 Apsolutne
\par }{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 1. postavljena sumnja i dijagnoza korioamnionitisa
\par }{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid8284272 2. ativna tuberkuloza }{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 
\par 3. porfirija 
\par }\pard\plain \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid12800265\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {
\f1\fs22\ul\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 Relativne
\par }\pard\plain \s18\ql \li0\ri720\sb100\sa100\sl360\slmult1\widctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\aspalpha\aspnum\faauto\adjustright\rin720\lin0\pararsid12800265\yts17 
\f2\fs24\lang1033\langfe1033\cgrid\langnp1033\langfenp1033 {\f1\fs22\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 1. }{\f1\fs22\cf1\lang1050\langfe1033\langnp1050\insrsid344270\charrsid9127599 upotreba betasimpatikomimetika        
\par    (ritodrin, terbutalin, salbutamol)
\par }\pard\plain \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posy3184\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid12800265\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {
\f1\fs22\cf1\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 2. vi\'9aekratne doze}{\f1\fs22\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 \cell }\pard\plain 
\ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\lang1050\langfe1050\langnp1050\insrsid344270\charrsid9127599 \trowd \irow1\irowband1\lastrow 
\ts17\trgaph108\trrh3106\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposy3184\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth1\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4644\clshdrawnil \cellx4536\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth4644\clshdrawnil \cellx9180\row }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9127599 {\f1\lang1050\langfe1050\langnp1050\insrsid15549543 KS \endash  kortikosteroidi, PPPO}{
\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599  \endash  prij}{\f1\lang1050\langfe1050\langnp1050\insrsid8073250 evremeno prsnu\'e6e plodovih ovoja.}{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599  
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid8073250 
\par }{\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963  
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985\charrsid10567963 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid16409985 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599 
\par 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid6780980 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid15494027 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9127599 {\f1\lang1050\langfe1050\langnp1050\insrsid8284272 
\par 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid4867563 
\par 
\par 
\par 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 Tablica 2.
\par 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid15549543 Maj\'e8in}{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 i i novoro\'f0ena\'e8ki rizici antenatalne primjene kortikosteroida
\par }{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }\trowd \irow0\irowband0\ts17\trgaph108\trrh743\trleft-720\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10080\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth5760\clshdrawnil \cellx5040\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4320\clshdrawnil \cellx9360
\pard\plain \qc \li0\ri0\nowidctlpar\intbl\faauto\rin0\lin0\pararsid2646819\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\f1\fs28\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }{\f1\fs28\lang1050\langfe1050\langnp1050\insrsid15549543 Maj\'e8in}{\f1\fs28\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 i rizici
\par }{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \cell }{\f1\fs28\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 Novoro\'f0ena\'e8ki rizici}{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \cell }\pard\plain 
\ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \trowd \irow0\irowband0\ts17\trgaph108\trrh743\trleft-720
\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10080\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth5760\clshdrawnil \cellx5040\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4320\clshdrawnil \cellx9360
\row }\trowd \irow1\irowband1\ts17\trgaph108\trrh2655\trleft-720\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10080\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth5760\clshdrawnil \cellx5040\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4320\clshdrawnil \cellx9360
\pard\plain \ql \li0\ri0\nowidctlpar\intbl\faauto\rin0\lin0\pararsid10901496\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }{\f1\ul\lang1050\langfe1050\langnp1050\insrsid2646819 
\par }{\f1\ul\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 Kratkoro\'e8ni
\par 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \endash   plu\'e6ni edem  (KS u kombinaciji s }{\f50\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \'e2}{
\f1\lang1050\langfe1050\super\langnp1050\insrsid9127599\charrsid9127599 2}{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599  agonistima)
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid15549543 \endash   infekcija  (KS kod PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 a)
\par \endash   pote\'9ako\'e6e u kontroli DM tip I ili gestacijskog
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid10901496     }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 diabetesa}{\f1\lang1050\langfe1050\super\langnp1050\insrsid9127599\charrsid9127599 *
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \endash   pote\'9ako\'e6e u dijagnostici DM}{\f1\lang1050\langfe1050\super\langnp1050\insrsid9127599\charrsid9127599 *
\par }{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \cell }{\f1\ul\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 Kratkoro\'e8ni
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par \endash   infekcija (rijetko)
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid10901496 \endash   }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 supresija funkcije nabubre\'9ene }{\f1\lang1050\langfe1050\langnp1050\insrsid10901496    
\par     }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \'9eljezde (rijetko)
\par }{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \cell }\pard\plain \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {
\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \trowd \irow1\irowband1\ts17\trgaph108\trrh2655\trleft-720\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \trftsWidth3\trwWidth10080\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 
\clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth5760\clshdrawnil \cellx5040\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4320\clshdrawnil 
\cellx9360\row }\trowd \irow2\irowband2\lastrow \ts17\trgaph108\trrh1007\trleft-720\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\trftsWidth3\trwWidth10080\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb
\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth5760\clshdrawnil \cellx5040\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4320\clshdrawnil \cellx9360
\pard\plain \ql \li0\ri0\nowidctlpar\intbl\faauto\rin0\lin0\pararsid10901496\yts17 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {\f1\ul\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par Dugoro\'e8ni
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par \endash   nisu zabilje\'9eeni ozbiljniji rizici
\par }{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \cell }{\f1\ul\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par Dugoro\'e8ni
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par \endash   nepoznati
\par }{\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \cell }\pard\plain \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 \f2\fs24\lang1033\langfe1050\cgrid\langnp1033\langfenp1050 {
\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 \trowd \irow2\irowband2\lastrow \ts17\trgaph108\trrh1007\trleft-720\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \trftsWidth3\trwWidth10080\trftsWidthB3\trftsWidthA3\trautofit1\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\tbllkhdrrows\tbllklastrow\tbllkhdrcols\tbllklastcol \clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 
\clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth5760\clshdrawnil \cellx5040\clvertalc\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth4320\clshdrawnil 
\cellx9360\row }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9127599 {\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 * Antiinzulinski u\'e8inak KS \endash  prolazna hiperglikemija nakon primjene KS}{
\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9927774 {\f1\lang1050\langfe1050\langnp1050\insrsid15549543 KS \endash  kortikosteroidi, PPPO}{\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599  \endash  prijeremeno prsnu\'e6
}{\f1\lang1050\langfe1050\langnp1050\insrsid9127599 e plodovih ovoja, DM \endash }{\f1\lang1050\langfe1050\langnp1050\insrsid9927774  dijabetes melitus}{\f1\lang1050\langfe1050\langnp1050\insrsid8073250 .}{
\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid9127599 {\f1\lang1050\langfe1050\langnp1050\insrsid9127599\charrsid9127599 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid9127599 
\par }{\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13974474 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid13974474 {\f1\lang1050\langfe1050\langnp1050\insrsid1795582 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid8412060 {\f1\lang1050\langfe1050\langnp1050\insrsid13592364 Tablica 3}{\f1\lang1050\langfe1050\langnp1050\insrsid7611731 .
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid8412060\charrsid8412060  }{\f1\lang1050\langfe1050\langnp1050\insrsid8412060\charrsid2849482 Usporebda}{\f1\lang1050\langfe1050\langnp1050\insrsid2102669  prednosti i rizika}{
\f1\lang1050\langfe1050\langnp1050\insrsid8412060  }{\f1\lang1050\langfe1050\langnp1050\insrsid8412060\charrsid2849482 vi\'9aekratnih }{\f1\lang1050\langfe1050\langnp1050\insrsid8412060 i}{\f1\lang1050\langfe1050\langnp1050\insrsid8412060\charrsid2849482 
 jednokratnih antenatalnih doza KS}{\f1\lang1050\langfe1050\langnp1050\insrsid8412060 
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid13974474 {\f1\lang1050\langfe1050\langnp1050\insrsid13974474 
\par }{\f1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid2849482 
\par 
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13974474 
\par }\trowd \irow0\irowband0\ts11\trgaph108\trrh841\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Studija\cell Metoda\cell   N       \cell Indikacije za ulazak u studiju\cell Vrsta KS\cell Promatrano\cell Broj VD\cell Broj JD\cell Frekvencija  davanja KS}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid5592568 / broj doza }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell RR, CI , p\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow0\irowband0\ts11\trgaph108\trrh841\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 
\clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\trowd \irow1\irowband1\ts11\trgaph108\trrh850\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 
\clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Aghajafari }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.\cell MA
\par }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 8 }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 S.\cell ND\cell Trudno\'e6e 24 \endash  34 tjedana, data jedna ili vi\'9ae doza KS\cell Betametozon  
\par ( 2 x l2 mg.)
\par Deksametazon
\par (4 x 6 mg.)\cell RDS
\par 
\par END\cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474 ND}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474 ND}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell 1 / 
\par >=2\cell OR 0.79
\par CI [0.64-0.98]
\par OR 3.42
\par CI[1.92-6.11]\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow1\irowband1\ts11\trgaph108\trrh850\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Guinn }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid8412060 i}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid8794879  }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 P}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 RS\cell 502\cell Zbog PPI 24. \endash  34. tjedana, data jedna doza KS, a trudno\'e6a trajala > 7 dana od davanja prve doze KS    \cell Betametozon  
\par ( 2 x l2 mg.)
\par Deksametazon
\par (4 x 6 mg.)\cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 SNP}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell 256\cell 246\cell Tjed}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid5592568 no}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  /
\par 1 / >=2\cell 22.5% / 28%
\par RR 0.8
\par CI [ 0.59-1.10]\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow2\irowband2\ts11\trgaph108\trrh850\trleft-108\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\trowd \irow3\irowband3\ts11\trgaph108\trrh834\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 
\clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Jazayeri }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid5592568  }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 sur.\cell RS\cell 204\cell Trudno\'e6a < 35 tjedna, data jedna ili tjedne doze KS \cell Betametozon  
\par ( 2 x l2 mg.)
\par Deksametazon
\par (4 x 6 mg.)\cell RDS
\par 
\par }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 SNP}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell 61\cell 143\cell Tjed}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid5592568 no}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  / 
\par 1 / >=2\cell OR 1.3
\par CI [1.02-1.8]  OR 1.3
\par CI [1.04-1.7]\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow3\irowband3\ts11\trgaph108\trrh834\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\trowd \irow4\irowband4\ts11\trgaph108\trrh832\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 
\clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Dirnberger }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.\cell RS\cell 115\cell Trudno
\'e6e 27 \endash  32 tjedana, data jedna ili vi\'9ae doza KS\cell Betametozon  
\par ( 2 x l2 mg.)
\par \cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15549543 KPB}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell 55\cell 60\cell 1 /
\par  >=2\cell p > 0.05\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow4\irowband4\ts11\trgaph108\trrh832\trleft-108\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\trowd \irow5\irowband5\ts11\trgaph108\trrh842\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 
\clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Banks i sur.
\par NATRHS}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid8412060  }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell RS\cell 710\cell Trudno\'e6e 25 \endash  32 tjedana, data jedna ili vi\'9ae doza KS\cell Betametozon  

\par ( 2 x l2 mg.)
\par Deksametazon
\par (4 x 6 mg.)\cell TT
\par 
\par }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 NP}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell ND\cell ND\cell 1 /  
\par >=2 / 
\par >=3\cell (>=2)
\par p =0.02
\par (>=3)
\par p =0.01, OR 2.8\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow5\irowband5\ts11\trgaph108\trrh842\trleft-108\trbrdrt
\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\trowd \irow6\irowband6\ts11\trgaph108\trrh839\trleft-108\trbrdrt\brdrs\brdrw10 \trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv
\brdrs\brdrw10 \tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 
\clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Abbasi }{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.
\par \cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 RS\cell 369\cell Trudno\'e6e 24 \endash  34 tjedana, data jedna ili vi\'9ae doza KS\cell Betametozon  
\par ( 2 x l2 mg.)
\par \cell RDS
\par 
\par END\cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15948676 153}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15948676 216}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell 1 /
\par >=2\cell 35%/45%
\par p=0.005
\par 
\par p=0.013\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow6\irowband6\ts11\trgaph108\trrh839\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Murphy }{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.\cell }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid5592568 R}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 S\cell 1039\cell Blizana\'e8ka trudno\'e6a, 24 \endash  32 tjedana trudno\'e6e, data jedna ili vi\'9ae doza KS \cell 
Betametozon  
\par ( 2 x l2 mg.)
\par Deksametazon
\par (4 x 6 mg.)\cell RDS
\par 
\par TT\cell 136\cell 902\cell Svaka 2 tjedna/
\par 1/ >=2\cell OR 0.7
\par CI[0.2-2.0]
\par 
\par p=0.008\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow7\irowband7\ts11\trgaph108\trrh839\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Elimian }{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.\cell }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 RS\cell 354\cell Trudno\'e6a < 34 tjedana, data jedna ili vi\'9ae doza KS, TT pri ro\'f0enju < 1750 grama\cell Betametozon  
\par ( 2 x l2 mg.)
\par Deksametazon
\par (4 x 6 mg.)\cell RDS
\par 
\par US\cell 93\cell 261\cell 1 / 
\par >=2\cell 18%/41%
\par p<0.001
\par 43%/57%
\par p=0.02\cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow8\irowband8\ts11\trgaph108\trrh839\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\pard \ql \li0\ri0\nowidctlpar\intbl\pvpg\phmrg\posxc\posy2344\dxfrtext180\dfrmtxtx180\dfrmtxty0\faauto\rin0\lin0\pararsid13974474 {
\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 Pratt L. }{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid3811791 I}{\f36\fs20\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sur.}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell RS\cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15948676 ND}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell Trudno\'e6
a < 34 tjedana, data jedna ili vi\'9ae doza KS\cell Betametozon  
\par ( 2 x l2 mg.)
\par \cell SO
\par RDS
\par }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 MI i }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 NI\cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15948676 ND}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15948676 ND}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \cell 1 /
\par >=2\cell p < 0.01
\par p > 0.05
\par p > 0.05
\par \cell }\pard \ql \li0\ri0\widctlpar\intbl\aspalpha\aspnum\faauto\adjustright\rin0\lin0 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 \trowd \irow9\irowband9\lastrow \ts11\trgaph108\trrh839\trleft-108\trbrdrt\brdrs\brdrw10 
\trbrdrl\brdrs\brdrw10 \trbrdrb\brdrs\brdrw10 \trbrdrr\brdrs\brdrw10 \trbrdrh\brdrs\brdrw10 \trbrdrv\brdrs\brdrw10 
\tpvpg\tphmrg\tposxc\tposy2344\tdfrmtxtLeft180\tdfrmtxtRight180\trftsWidth3\trwWidth11483\trftsWidthB3\trftsWidthA3\trpaddl108\trpaddr108\trpaddfl3\trpaddfr3 \clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr
\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1101\clshdrawnil \cellx993\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth850\clshdrawnil \cellx1843\clvertalt\clbrdrt
\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth602\clshdrawnil \cellx2445\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth2409\clshdrawnil \cellx4854\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx6272\clvertalt\clbrdrt\brdrs\brdrw10 
\clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx7406\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth709\clshdrawnil \cellx8115\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth708\clshdrawnil \cellx8823\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl
\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 \cltxlrtb\clftsWidth3\clwWidth1134\clshdrawnil \cellx9957\clvertalt\clbrdrt\brdrs\brdrw10 \clbrdrl\brdrs\brdrw10 \clbrdrb\brdrs\brdrw10 \clbrdrr\brdrs\brdrw10 
\cltxlrtb\clftsWidth3\clwWidth1418\clshdrawnil \cellx11375\row }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0\pararsid14571128 {\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 N \endash  broj, KS \endash 
 kortikosteroidi, VD \endash  vi\'9aekratne doze, JD \endash  jedna doza,}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid14571128  }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid13974474 MA \endash  meta-analiza}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128 ,}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid14571128  }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 S \endash  }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128 studija,}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid14571128  }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid13974474 ND \endash  nije dostupno}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128 ,}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid14571128  }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 RDS \endash  respiratorni distres}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid13974474  sindrom}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128 ,}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid14571128  }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128\charrsid13974474 END \endash  endometritis}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128 ,}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006  P}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 RS }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 \endash  prospektivna }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 
randomizirana studija, PPI \endash  prijete\'e6i prijevremen}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 i porod, SNP \endash  slo\'9eeni novoro\'f0ena\'e8kii pobol}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 
 (III-IV stupanj RDSa, bronhopulmonalnu displazij}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid8073250 u (BPD), III-IV stupanj IKK}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 , periventrikularnu}{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006  leukomalaciju (PVL), novoro\'f0ena\'e8ku}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  sepsu (NS), nekrotiziraju\'e6i }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 enterokolitis (NE) i perinatalnu smrtnost (PS}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 )}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid14571128 ), RS \endash 
 retrospektivna studija}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid15549543 , KPB}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  \endash  kroni\'e8na plu\'e6na bolest, TT \endash  }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 tjelesna te\'9eina, NP \endash  novoro\'f0ena\'e8ki pobol}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 , US \endash  upotreba surfaktanta, }{
\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 SO \endash  smanjena oksigenacija, IM}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474  \endash  infekcije majke}{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid1316006 
, IN \endash  infekcija }{\f36\fs20\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid13974474 novoro\'f0en\'e8eta
\par }\pard \ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0\pararsid13974474 {\f1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid2849482  
\par }\pard \ql \li0\ri0\sl360\slmult1\nowidctlpar\faauto\rin0\lin0\itap0 {\b\f1\cf1\lang1050\langfe1050\langnp1050\insrsid13974474\charrsid9127599 
\par }}