Naslov
Cancer micrometastasis detection and destruction using antibody coated superparamagnetic nanoparticles induced hyperthermia: current state of the art and perspectives of applications in the prostate metastatic cancer

Autori
Sabolović, Domagoj ; de Morais, Paulo Cesar ; da Silva, Maria de Fatima ; Barbić, Jerko ; Mori, Takeo ; Tucak, Antun

Izvornik
Medicinski vjesnik (0350-6487) 36 (2004), 1-4; 37-41

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Superparamagnetic nanoparticles; micrometastasis; prostate; magnetothermolysis; alternative magnetic field; in vivo cell targeting

Sažetak
Biomedical applications of nanotechology, such as early, in vivo disease detection and malignant cell destruction, were documented, using a small-sized superparamagnetic particles coated with specific antibodies. Antibody coated nanoparticles can be used as contrast markers in magnetic resonance imaging of targeted cells and at the same time in temperature induced specific destruction of these cells in situ, using external alternative magnetic field . Our experimental results corroborate this hypothesis. Combined diagnoses with treatments, many considerable applications of nanotechnology in biomedicine could be performed, depending on availability of appropriate antibodies. This paper describes strategy for future developments and multidisciplinary approach involved in the preparation and handling of nanoparticles and experimental design.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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