Pregled bibliografske jedinice broj: 159644
Genetic Studies of Complex Diseases: An Example of Hypertension in Croatian Population
Genetic Studies of Complex Diseases: An Example of Hypertension in Croatian Population // Anthroplogy and Health: Domains of Application in the 21st Century
Hvar, Hrvatska, 2004. (predavanje, međunarodna recenzija, neobjavljeni rad, znanstveni)
CROSBI ID: 159644 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Genetic Studies of Complex Diseases: An Example of Hypertension in Croatian Population
Autori
Barbalić, Maja ; Škarić-Jurić, Tatjana ; Smolej Narančić, Nina
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
Anthroplogy and Health: Domains of Application in the 21st Century
Mjesto i datum
Hvar, Hrvatska, 14.06.2004. - 18.06.2004
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
genetic studies; complex diseases; hypertension; Croatia
Sažetak
Genetics of complex diseases has become one of the most researched areas in molecular genetics and anthropology in recent years. Understanding the multifactorial nature of complex diseases presents a challenge to contemporary science of genetics and requires integration of knowledge about molecular genetic functioning of organism with statistical approaches that must be carried out to solve the complex network of causes leading to the onset of a complex disease. The two approaches most widely used in genetic studies of complex diseases susceptibility genes are linkage and association studies. Linkage studies are based on the fact that recombination occurs rarely between two adjacent genes. Their typical samples consist of family members who are expected to share alleles on a locus that is adjacent to an investigated disease locus. Association studies look for loci whose alleles occur more often in diseased subjects than in controls. These loci are not necessarily involved in the disease status but may stand in linkage disequilibrium with the disease gene. Hypertension is one of the most widely distributed complex diseases. It affects every third person in the western world and presents a major risk factor for cardiovascular diseases. In our research of hypertension in Croatian population, we investigated 6 polymorphisms in 3 candidate genes whose products are components of renin-angiotensin system that is one of the most important blood pressure control systems. Only one of investigated genes, gene coding for angiotensin-converting enzyme, seems to be associated to hypertension in Croatian population sample.
Izvorni jezik
Engleski
Znanstvena područja
Etnologija i antropologija
