Naslov
Lipoprotein(a) and C-reactive protein in children with cerebrovascular events

Autori
Zrinski Topić, Renata ; Coen, Desiree ; Fuček, Mirjana ; Miloš, Marija ; Leniček-Krleža, Jasna ; Dodig, Slavica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
18th International Congress on Thrombosis : Reports ; u: Pathophysiology of Haemostasis and Thrombosis (ISSN 1424-8832) 33 (2004) (S5/6) Special Issue / Stegnar, Mojca ; Božič, Mojca ; Kozak, Matija ; Peternel, Polona ; Vene, Nina - Basel : Freiburg : Paris : London : Karger Publishers, 2005, 50-50

ISBN
978-3-8055-7892-9

Skup
18th International Congress on Thrombosis (18 ; 2004)

Mjesto i datum
Ljubljana, Slovenija, 20.06.2004. - 24.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lipoprotein(a); C-reactive protein; cerebrovascular events
(ipoprotein(a); C-reactive protein; cerebrovascular events)

Sažetak
Cerebrovascular events in children, half of which are ischemic stroke, occur at an estimated incidence of about 2 per 100000 per year. The pathogenesis of atherosclerosis begins in childhood. Increased C-reactive protein (CRP) is a important predictor of cardiovascular events, independent of traditional risk factors. Elevated lipoprotein (a) (Lp(a)) has been identified as a genetically determined risk factor for stroke in young adults. Only preliminary data are available on theirs role as a risk factors for ischemic stroke in children. The aim of the study was to examine the prevalence of two atherosclerotic risk factors in children with cerebrovascular events. Serum samples were obtained 3-6 months after acute phase of disease from 29 children (17 males and 12 females ; age range 2-17 years) with a history of arterial ischemic stroke (AIS, n=14) and transient ischemic attack (TIA ; n=15). The diagnosis were based on patient's history, clinical and neurological examination. Control group was 26 healthy children (15 males and 11 females ; age range 2-15 years). CRP was measured by latex-enhanced nephelometry (N High Sensitivity CRP, Dade Behring). Lp(a) was quantified by immunoturbidimetric assay (Tina-quant, Roche Diagnostics). RESULTS: By using cut-off value for CRP of 1, 1 mg/L (90th percentile) we found a significantly higher frequency of elevated CRP values in children with a history of AIS (6 of 14 ; 43%) compared with control subjects (2 of 26 ; 8%). In addition, in this group of patients was higher frequency of Lp(a) values above 0, 3 g/L (4 of 14 ; 29%) compared with control subjects (5 of 26 ; 19%). No difference in frequency of CRP and Lp(a) values were abserved between children with a history of TIA and control group. Despite a low number of children in each group it seems that CRP and Lp(a) are important risk factor for arterial ischemic stroke in childhood.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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