Pregled bibliografske jedinice broj: 159476
Probabilistic kinetic model of slow oxidation of low-density lipoprotein ; hydroperoxide-free initiation
Probabilistic kinetic model of slow oxidation of low-density lipoprotein ; hydroperoxide-free initiation // HDBMB 2004 - Book of abstracts / Dumić, Jerka (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2004. str. 98-98 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 159476 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Probabilistic kinetic model of slow oxidation of low-density lipoprotein ; hydroperoxide-free initiation
Autori
Krilov, Dubravka ; Herak, N. Janko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
HDBMB 2004 - Book of abstracts
/ Dumić, Jerka - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2004, 98-98
Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology
Mjesto i datum
HOC Bjelolasica, Hrvatska, 30.09.2004. - 02.10.2004
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
alpha-tocopherol; pro-oxidant; atherosclerosis; LDL; oxidation; peroxidation kinetics; tocopherol-mediated peroxidation
Sažetak
PROBABILISTIC KINETIC MODEL OF SLOW OXIDATION OF LOW-DENSITY LIPOPROTEIN ; HYDROPEROXIDE-FREE INITIATION Dubravka Krilov1 and Janko N. Herak2 1Medical School, Šalata 3b, 2Faculty of Pharmacy and Biochemistry, A. Kovačića 1, University of Zagreb, 10000 Zagreb, Croatia, krilov@mef.hr Theoretical model is presented that explains slow copper-induced oxidation of low-density lipoprotein from human plasma in the systems free of seeded hydroperoxides. The LDL oxidation is assumed to be initiated by traces of the transition-metal ions associated with the lipoprotein. The theory assumes oscillation of the metal ions and a-tocopherol between the oxidized and the reduced states. In this model a-tocopherol acts as a pro-oxidant. The model is based on the probabilistic kinetic theory, modified to take into account different radical generation rates by oxidized and reduced forms of the metal ions. The differential equations describing the initial radical generation rate and the rates of change of concentration of oxygen, hydroperoxide and co-antioxidant in an LDL system are numerically solved in a finite difference approach. It is shown that the initiation and progression of LDL oxidation can take place in any LDL dispersion containing at least a minute amount of the reduced form of the metal ions. Selected values of several adjustable parameters define actual temporal profiles of the quantities defining the oxidation process.
Izvorni jezik
Engleski
Znanstvena područja
Fizika
