Naslov
Systemic immunotoxicity in mice induced by whole body inhalation exposure to gasoline and diesel exhaust

Autori
Jakovac, Hrvoje ; Mrakovčić-Šutić, Ines ; Bulog, Aleksandar ; Grebić, Damir ; Mićović, Vladimir ; Radošević-Stašić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book / Jonjić, Stipan - Rijeka : Hrvatsko imunološko društvo, 2004, 49-49

Skup
Annual meeting 2004, Croatian Immunological Society

Mjesto i datum
Opatija, Hrvatska, 19.06.2002. - 22.06.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Intrahepatic lymphocytes; NK cells; inhalation; gasoline; diesel
(ntrahepatic lymphocytes; NK cells; inhalation; gasoline; diesel)

Sažetak
Epidemiological research has established an association between human exposures to environmental pollutants and a variety of cardiopulmonary diseases, including inflammatory pulmonary diseases and asthma, and development of carcinomas. Effects were attributed particularly to polycyclic aromatic hydrocarbons, such as benzene and naphthalene, which are the components of diesel exhaust particles, but also to a variety of other ambient particulate matter, which affect local and systemic immune and inflammatory responses. The purpose of this study was to determine the effects of an acute whole body inhalation exposure of mice to gasoline (G) and diesel (D) vapour on phenotypic profile of hepatic and splenic mononuclear lymphatic cells (MNLC). METHODS: C57/BL6 mice were exposed daily for 11 days (1 h/day) to atmospheres containing gasoline and diesel vapour, which were drown in whole body exposure chambers, containing soda lime for absorption of CO2.The effects were compared to chamber exposure control mice receiving fresh air. Measuring of NK cells, NKT cells, subpopulation of T and B cells in the liver and in the spleen assessed G and D effects. RESULTS: The preliminary data have shown that the whole body inhalation exposure of mice to gasoline and diesel exhaust might affect particularly the composition of MNLC the liver. Thus, in G-exposed group the significant decline of hepatic NKT cells was noticed. The difference were, however found also between the G and D-exposed group, as well as between the mice, closed in the chamber, and unrestrained mice, showing that mechanism involve not only the toxic effects of environmental pollutants, but also the effects of stress.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA