Naslov
Macrophages of human first trimester decidua express markers associated to alternative activation.

Autori
Ćupurdija, Kristijan ; Azzola, Dagmar ; Hainz, Ursula ; Gratchev, Alexei ; Heitger, Andreas ; Takikawa, Osamu ; Goerdt, Sergij ; Wintersteiger, Reinhold ; Dohr, Gottfried ; Sedlmayr, Peter

Izvornik
American journal of reproductive immunology (1046-7408) 51 (2004); 117-122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Macrophages; Decidua; Pregnancy;

Sažetak
PROBLEM: Depending on the type of their activation, macrophages may promote TH1- or TH2-type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which - together with NK cells - constitute the majority of bone marrow derived cells at this location. METHOD OF STUDY: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mphi2). RESULTS: The markers MS-1 (stabilin-1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMphi). In contrast, indoleamine 2, 3-dioxygenase (IDO), an enzyme induced in macrophages by IFNgamma, was not present in DMphi. CONCLUSIONS: First trimester DMphi display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMphi are not under a predominant influence of IFNgamma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA