Naslov
CXCR3 i CCR5 omogućavaju migraciju T-limfocita u cerebrospinalni likvor kod bolesnika s akutnim virusnim meningoencefalitisom
(CXCR3 and CCR5 mediate T-cell accumulation into the cerebrospinal fluid of patients with acute viral meningoencephalitis)

Autori
Židovec Lepej, Snježana ; Baršić, Bruno ; Vince, Adriana ; Đaković Rode, Oktavija ; Remenar, Anica ; Jeren, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Croatian immunological society annual meeting 2004, October 8.-10. 2004, Opatija / - Rijeka, 2004, 27-27

Skup
Annual Meeting of the Croatian immunological society

Mjesto i datum
Opatija, Hrvatska, 08.10.2004. - 10.10.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
CXCR3 CCR5 cerebrospinalni likvor virusni meningoencefalitis
(CXCR3 CCR5 cerebrospinal fluid viral meningoencephalitis)

Sažetak
CXCR3 AND CCR5 MEDIATE T-CELL ACCUMULATION IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ACUTE VIRAL MENINGOENCEPHALITIS Snježana Židovec Lepej, Bruno Baršić, Adriana Vince, Oktavija Đaković Rode, Anica Remenar, Tatjana Jeren University Hospital for Infectious Diseases &#8220; Dr. Fran Mihaljević&#8221; , Zagreb, Croatia Infiltration of haematogenous lymphocytes into brain tissue is a crucial step in the pathogenesis of inflammatory central nervous system diseases (CNS). The migration of lymphocytes across the blood brain barrier is mediated by adhesion molecules, chemokine receptors and their corresponding ligands. Chemokine receptors CXCR3 and CCR5 are expressed on T-cells of predominantly Th1 phenotype and have been detected on T-cells isolated from a variety of inflamed tissues. The aim of this study was to investigate the role of chemokine receptors CXCR3 and CCR5 in the recruitment of T-cells into the cerebrospinal fluid (CSF) of patients with acute viral meningoencephalitis. We compared the distribution of CXCR3 and CCR5 on T-cells from the CSF and peripheral blood (PB) of 20 patients with acute viral meningoencephalitis by flow cytometry. The majority of CD4+ T-cells in the CSF were of memory phenotype (CD45RO+). Percentages of CCR5+CD45RO+CD4+ T-cells were significantly enriched in the CSF (median 60.1%, range from 39.5-72.3) compared with the PB (median 13.1%, range from 2.9-35-7%, p<0.001). Similarly, percentages of CXCR3+CD45RO+CD4+ T-cells in the CSF (median 66.3%, range from 15.6-76.5%) were significantly higher compared with the PB (median 17.5%, range from 5.6-28.4%, p<0.001). Our results suggest that CXCR3 and CCR5 mediate the selective accumulation of memory CD4+ T-cells in the CSF of patients with acute viral meningoencephalitis. We hypothesize that CCR5 and CXCR3 might represent important molecular targets for chemokine receptor antagonist therapy in human inflammatory CNS diseases.

Izvorni jezik
Engleski

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