Naslov
Cytokines and hormones in the regulation of perforin expression in the decidual lymphocytes

Autori
Rukavina, Daniel ; Laškarin, Gordana ; Štrbo, Nataša ; Sotošek, Vlatka ; Bedenicki, Ivica ; Podack, Eckhard R.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the Fourth International Meeting "Mechanisms in Local Immunity" and joint meeting Fourth Meeting of Alps Adria Society for Immunology of Reproduction (AASIR) ; u: Periodicum Biologorum. Supplement 99 (1998) / Vitale, Branko - Zagreb : Hrvatsko prirodoslovno društvo, 1998, 41-41

Skup
International Meeting "Mechanisms in Local Immunity" (4 ; 1998) ; Meeting of Alps Adria Society for Immunology of Reproduction (4 ; 1998)

Mjesto i datum
Opatija, Hrvatska, 16.09.1998. - 19.09.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
perforin; pregnancy; IL-10; IL-12; IL-15

Sažetak
Cell populations in the decidua of pregnancy are heterogeneous and besides stromal cells include bone marrow derived immune cells: macrophages, large granular lymphocytes (LGL) and T lymphocytes. Immune cells infiltrating decidua are constantly targeted by placental hormones and cytokines, produced at the materno-fetal interface and acting in a paracrine or autocrine manner. Cytokines of TH2 type (IL-4, IL-6, IL-10, IL-15, TGFbeta) seem to be predominantly produced rather than those of TH1 type. LGL have an NK like phenotype (CD3+CD56brightCD16+), they are armed with the strong cytolytic potential (Perforin-Pbright+), but exhibiting much lower cytotoxic potential than corresponding PBL. Experiments with perforin deficient animals showed the role of P+ cells in homeostatic regulation of the immune response by lyzing antigen presenting cells and preventing excessive T cell activation. From the other side, decidual macrophages have an important role in maintenance and up-regulation of P expression in decidual LGL. These effects are mediated by humoral products and could be ascribed to IL-15 and progesterone, and its mediator (PIBF). IL-2, the most potent stimulator of P expression in PBL, is almost completely absent from the decidua, as well as his high affinity receptor (CD25), which can explain IL-2 inefficiency in upregulation of P expression. In decidua IL-15 exhibits many biological activities ascribed to IL-2, including upregulation of P expression. The role of cytokines IL-10 and IL-12 and IFNgama was also investigated. The results point to the existence of hormonal/cytokine network regulating activation of cytolytic pathways at the maternal-fetal interface.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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