Pregled bibliografske jedinice broj: 157759
New approach to drug delivery into the cells
New approach to drug delivery into the cells // International Conference on the Interfaces among Mathematics, Chemistry & Computer science / Graovac, Ante (ur.).
Zagreb, 2003. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 157759 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
New approach to drug delivery into the cells
Autori
Grdiša, Mira
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
International Conference on the Interfaces among Mathematics, Chemistry & Computer science
/ Graovac, Ante - Zagreb, 2003
Skup
18th International Conference on the Interfaces among Mathematics, Chemistry & Computer science
Mjesto i datum
Dubrovnik, Hrvatska, 20.06.2003. - 25.06.2003
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
drug delivery; TAT-vector
Sažetak
Plasma membrane - tight barriers against gene/protein transfer -intracellular therapeutic use of proteins, peptides, oligonucleotides - limited - impermeable nature of the cell membrane - efficient intracellular drug and DNA delivery - to target micropartuculate drug carriers into cytoplasm bypassing the endocytotic pathway - TAT peptides derived from HIV-1 TAT protein - intracellular delivery of proteins and small colloidal particles -compounds and proteins to combat - viral infections - cancer cells - complement genetic deficiencies -deliver of pharmacologically relevant compounds/ proteins - limited by physical properties drugs - enter cells by passive diffusion - uptake and lipid solubility correlate positively
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
