Naslov
Liposome-encapsulated superoxide dismutase increased activity of superoxide dismutase in epithelial cells

Autori
Galović-Rengel, Ružica ; Barišić, Karmela ; Filipović-Grčić, Jelena ; Pavelić, Željka ; Čepelak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Prvi hrvatski kongres za molekularne bioznanosti s međunarodnim sudjelovanjem

Mjesto i datum
Opatija, Hrvatska, 09.06.2002. - 13.06.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
liposomes; superoxide dismutase; carcinoma cells

Sažetak
Superoxide dismutase (SOD) was encapsulated into liposomes in order to increase its releasing time and to facilitate its cellular penetration. Positively, neutrally and negatively charged liposomes were prepared by the proliposome method using soybean lecithin, stearylamine, phosphatidylglycerol and cholesterol. The efficiency of SOD entrapment was 39-65%. A2182, human lung carcinoma cells, were treated with liposome encapsulated SOD, 20 U/ml of media. All liposome preparations were successfully delivered SOD to the cells. The biggest increase in the activity was achieved by negatively charged liposomes.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA