Naslov
Multicomponent complexes of piroxicam with cyclodextrins and hydroxypropyl methylcellulose

Autori
Jug, Mario ; Bećirević-Laćan, Mira

Izvornik
Drug development and industrial pharmacy (0363-9045) 30 (2004), 10; 1051-1060

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
piroxicam; cyclodextrins; hydroxypropyl methylcellulose; multicomponent complexes

Sažetak
The purpose of the study was to investigate the effect of hydroxypropyl methylcellulose (HPMC) on the complexation of piroxicam (PX) with beta-cyclodextrin (beta-CD) and dimethyl-beta-cyclodextrin (DM-beta-CD) in solution and in the solid state. Phase solubility study revealed a positive effect of the polymer on the drug complexation. Improvement in stability constants values. Ks, of ternary complexes clearly proves the benefit of the HPMC addition for promoting higher complexation efficiency. Solid binary and ternary complexes were prepared by spray drying. Drug-CD and drug-CD-polymer interactions were studies in the solid state by differential scanning calorimetry (DSC)), zeta-potential measurements, and particle size distribution. A marked increase in the PX dissolution rate was observed even in binary and ternary complexes. The presence of HPMC in ternary complexes slightly retarded the release of PX. Cyclodextrin complexation increased the PX concentration gradient over the semipermeable membrane, resulting in an increased PX flux. The retarded diffusion of PX to the membrane interface decreased the PX to the membrane interface decreased th PX flux values of the ternary complexes.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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