Naslov
The consequences of insulin-like growth factors/receptors dysfunction in lung cancer

Autori
Pavelić, Jasminka ; Križanac, Šimun ; Kapitanović, Sanja ; Pavelić, Ljubomir ; Samaržija, Miroslav ; Pavičić, Fadila ; Spaventi, Šime ; Jakopović, Marko ; Herceg-Ivanovi, Zlata ; Pavelić, Krešimir

Izvornik
American journal of respiratory cell and molecular biology (1044-1549) 32 (2005); 65-71

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
insulin-like growth factors; lung cancer

Sažetak
The aim of this study was to investigate the consequences of IGFs/IGF receptors dysfunction in lung carcinomas. A correlation between increased expression (at mRNA and protein levels) for both, IGF 1 and IGF 1R, and decreased apoptosis rate was found in large cell carcinomas and adenocarcinomas. In both tumor types mutations in M6P/IGF 2R gene were also found. The findings suggest that disturbation of the IGFs/IGF receptors axis is involved in lung cancer formation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA