Naslov
On invariants of a 2-D proteome map derived from neighborhood graphs

Autori
Randić, Milan ; Lerš, Nella ; Plavšić, Dejan ; Basak, Subhash C.

Izvornik
Journal of proteome research (1535-3893) 3 (2004), 4; 778-785

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
proteome maps; map invariants; neighborhood graphs; W-NN matrix; peroxisome proliferators

Sažetak
We consider the problem of the construction of invariants for characterization of 2-D maps, such as 2-D proteome maps, 2-D NMR spectral maps, etc., that in addition to facilitating cataloguing such maps can be used for comparison of maps and numerical evaluation of their degree of similarity. A novel approach, based on the concept of the nearest neighborhood of points (spots) on a map are sufficiently flexible to allow one not only to vary the number of points used for characterization of the map but also the density of information on their relative positions, is put forward. The method is illustrated with the Coomassie brilliant blue stained 2-D gel electrophoresis patterns of the proteomes from liver cells of healthy mail Fisher F344 rats and the rats treated with four peroxisome proliferators.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA