Naslov
Periacinar retraction clefting in the needle core biopsies, an important diagnostic criterion or a simple artifact?

Autori
Krušlin, Božo ; Tomas, Davor ; Rogatsch, Hermann ; Novosel, Irena ; Čupić, Hrvoje ; Belicza, Mladen ; Kraus, Ognjen ; Mikuz, Gregor

Izvornik
Virchows archiv (0945-6317) 443 (2003), 5; 524-527

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostate; adenocarcinoma; histologic criteria; retraction clefting; needle core biopsy

Sažetak
The diagnosis of prostatic adenocarcinoma in needle core biopsy is based on major and supportive criteria. One of the supportive criteria is the presence of retraction clefting around neoplastic glands. We analyzed a series of 137 prostatic cancer cases diagnosed by needle core biopsy to determinate the frequency, extent and criteria for periacinar retraction clefting. Clefting was analyzed on 10 neoplastic and 10 normal glands in three different high power fields. One third or more glands with clefts affecting more than 50% of circumference, were significantly more common in tumors (51.8%) than in benign glands (8%) (p<0.0001). A stricter criterion that designated as positive the cases with at least 50% of neoplastic glands (fifteen out of thirty) with clefts that affected more than 50% of circumference revealed clefts in only 15.3% of the malignant cases but not in benign cases (0%) (p<0.0001). Fifteen or more glands with clefts regardless of their extension were also more prominent in malignant cases (86.9%) than in benign cases (20.4%) (p<0.0001). We conclude that periacinar retraction clefting represents a reliable criterion for diagnosis of the prostatic adenocarcinoma, especially in cases with clefts affecting more than 50% of circumference in at least 50% of suspicious glands.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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