Naslov
Voltammetric assay of azithromycin in pharmaceutical dosage forms

Autori
Nigović, Biljana ; Šimunić, Branimir

Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 32 (2003), 1; 197-202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azithromycin; differential pulse voltammetry; electrochemical oxidation; pharmaceutical analysis

Sažetak
The oxidative behaviour of azithromycin was studied at s glassy carbon electrode in different buffer system using cyclic, linear sweep and differential pulse voltammetry. The oxidation process was shown to be irreversible over the entire pH range studied (5-11) and was diffusion-adsorption controlled. Analytical method with adequate precision and accuracy was developed for the determination of azithromycin in phosphate buffer at pH 7 as supporting electrolyte containing 10% methanol and 0.05 M ammonium acetate. The peak current varied linearly with azithromycin concentration in the range 1-15 mug/ml. The procedure was successfully applied for assay of the drug in the pharmaceutical dosage forms. The relative standard deviation (n = 5) of 2.18% was obtained.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA