Naslov
The Haem-Accessibility to Solvent and Allosteric Effects in Different Protomers of Human Hemoglobin as Observed by Proton Magnetic Relaxation

Autori
Vuk-Pavlović, Stanimir ; Benko, Bojan ; Maričić, Siniša ; Markovska, B. ; Efremov, G. D

Izvornik
International journal of biochemistry (0020-711X) 7 (1976); 367-370

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Haemoglobin ; Inositol hexaphosphate ; Proton magnetic relaxation

Sažetak
1. The temperature dependence of the paramagneticlly induced molar solvent-proton longitudinal magnetic relaxation (PMR) rates in the phosphate-free solutions of aquomet derivatives of human haemoglobins A0 and A2 are almost identical. 2. The addition of inositol hexaphosphate to either of the solutions increases the PMR rates, but this effect is significantly smaller for HbA2. 3. Taking into account the non- equivalent influence of alpha and beta chains on PMR rates, it is concluded that the mechanism of transfer of allosteric intormation upon binding of inositol hexaphosphate is less effective in HbA2 than in HbA0. Some implications of this finding are discussed here.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija

POVEZANOST RADA