Naslov
The effect of cycloheximide treatment on butyrylcholinesterase activity in vivo

Autori
Lucić, Ana ; Radić, Božica ; Peraica, Maja ; Domijan, Ana-Marija ; Bradamante, Vlasta ; Fuchs, Radovan ; Žlender, Vilim

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Toxicology ; Abstracts of 5th Congress of Toxicology in Developing Countries / - , 2003

Skup
Congress of Toxicology in Developing Countries

Mjesto i datum
Guilin, Kina, 10.11.2003. - 13.11.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cycloheximide; BuChE; plasma; liver; white adipose tissue; heart; brain

Sažetak
The paper describes the catalytic activity of butyrylcholinesterase (BuChE) measured in plasma, liver, white adipose tissue, heart, and brain of rats intraperitoneally administered a single non-lethal dose of cycloheximide (2.0 mg/kg body weight ; CHM). The BuChE assay was performed on rats of both sexes either treated with CHM or saline (controls), and killed 2, 3, 4, 5 and 10 days later. A significant decrease of BuChE catalytic activity was observed in all tested tissues except plasma. In animals of both sexes the lowest BuChE catalytic activity was found in liver (2-6 %), while it was higher in white adipose tissue, heart, and brain. However, the respective values remained significantly different from controls (33-67%, 49-62%, and 14-71 % in males, and 24-82%, 72-86%, and 33-67 % in females). Since there was no effect of CHM on BuChE catalytic activity in plasma, the data suggest that CHM inhibits the synthesis of BuChE rather than catalytic activity of enzyme.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA