Naslov
Adamantanski derivati tenociklidina : djelotvorni radioprotektori
(Adamantane derivatives of tenocyclidine : effective radioprotective agents)

Autori
Ferle-Vidović, Ana ; Smoljan, Branko ; Jukić, Ivan ; Škare, Danko

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Zbornik radova Četvrtog simpozija Hrvatskog društva za zaštitu od zračenja / Franić, Zdenko ; Obelić, Bogomil - Zagreb : Hrvatsko društvo za zaštitu od zračenja, 1998, 75-79

Skup
4. Simpozij Hrvatskog društva za zaštitu od zračenja

Mjesto i datum
Zagreb, Hrvatska, 11.11.1998. - 13.11.1998

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Sažetak
A slight radioprotective effects of phencyclidine (PCP) and more effectivnes of its adamantilamine derivatives has been found. Many attempts have been done in order to change the chemical structure of PCP mainly by addition of some active groups to its basic structure, to improve its pharmacological properties. Regarding the before mentioned weak radioprotective effect of PCP and reduced toxicity of its adamantylamine derivatives (without sulphur), we prepared tienil phencyclidine (TCP) and three of its adamantil derivatives (with sulphur). We tested in cultured cells to see if this compounds has more radioprotective properties in comparison with PCP and its adamantyl derivatives or than the basic structure of TCP. The results with cells in the present paper show that the piperidine derivative of adamantyl phencyclidine, has rather outstanding radioprotective properties. This derivative revealed significant radioprotection at all survival levels.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA