Naslov
Met-enkephalin effects on the histamine induced bronchoconstriction in guinea-pigs

Autori
Tješić-Drinković, Dorian ; Štambuk, Nikola ; Tješić-Drinković, Duška ; Konjevoda, Paško ; Pokrić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts MATH/CHEM/COMP 2004 / Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko - Zagreb : Institut Ruđer Bošković, 2004, 81-81

Skup
MATH/CHEM/COMP 2004 - The 19th Dubrovnik International Course & Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences

Mjesto i datum
Dubrovnik, Hrvatska, 21.06.2004. - 26.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
asthma; bronhoconstriction; guinea-pig; met-enkephalin; modulatory effect

Sažetak
We investigated the effects of neuropeptide met-enkephalin on the histamine induced bronhoconstriction in guinea-pigs. Konzett and Rössler's method of whole body pletismography modified by Gjuriš, was applied to investigate the effects. This method represents standard in vivo model of asthma. Dose-related modulatory effect of met enkephalin on the bronchoconstrictor action of histamine was noticed and met enkephalin doses of 1 mg/kg and 10 mg/kg, respectively, caused significant reduction of the histamine induced bronchoconstriction. Further studies are needed to define practical and therapeutical use of the presented observations in chronic obstructive pulmonary diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA