Naslov
The influence of hyperbaric oxygen treatment on the Erk and Jnk activation signals in the hippocampus and optic nerves of global cerebral ischaemia exposed rats

Autori
Mršić-Pelčić, Jasenka ; Pelčić, Goran ; Vitezić, Dinko ; Simonić, Ante ; Župan, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 4th Congress of the Federation of the European Pharmacological Societies / - , 2004, 109-109

Skup
4th Congress of the Federation of the European Pharmacological Societies

Mjesto i datum
Porto, Portugal, 14.07.2004. - 17.07.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
global cerebral ischaemia; HBO treatment; Erk; Jnk; rat

Sažetak
Effects of the hyperbaric oxygen (HBO) treatment on the ERK and JNK activation signals in the hippocampus and optic nerves of rats exposed to global cerebral ischaemia were studied. Animals were exposed to global cerebral ischaemia (20 min duration) and after different reperfusion periods (5 and 10 min ; 1 ; 6 and 12 h after ischaemia), ERK and JNK activation signals were determined. A part of ischaemic animals were exposed to HBO after reperfusion during seven consecutive days, at 222, 86 kPa pressure of 99, 5% oxygen, lasting 60 min. Results: The activation signals of ERK and JNK in hippocampus and optic nerves of the ischaemic animals were registered during all reperfusion periods tested, but maximal activation was found 1 h after ischaemia. In the optic nerves, second strong activation signal was repeated after 12 h of reperfusion. After the HBO treatment, intensity of activation signals was decreased or suppressed during all reperfusion periods tested. Our results indicated that activation of ERK and JNK were implicated in early and a later periods of reperfusion injury such as that pretreatment with HBO may have a possible protective effect in cerebral ischaemia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA