Naslov
The role of aminopeptidase(s)in Met-enkephalin modulated superoxide anion release

Autori
Balog, Tihomir ; Marotti, Tanja ; Abramić, Maja ; Svoboda Beusen, Ivna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum biologorum 99 (suppl.2) 1997 ; Annual Meeting of the Croatian Immunological Society / Vitale, Branko ; Rabatić, Sabina - Zagreb : Hrvatsko prirodoslovno društvo, 1997, 19-19

Skup
Annual Meeting of the Croatian Immunological Society 1997

Mjesto i datum
Zagreb, Hrvatska, 06.11.1997. - 07.11.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
met-enkephalin; aminopeptidase; superoxide anion

Sažetak
In our previous study we observed a highly donor dependent effect of met-enkephalin (MENK) on superoxide anion release. The aim of this study was to examine if this donor dependent effect could be the consequence of diverse activity of proteolytic enzymes on the surface of neutrophils from different donors. According to the results obtained donors were classified in those with low, medium or high aminopeptidase activity. Neutrophils preincubated with MENK displayed significant decrease of aminopeptidase activity wich was not case with synthetic agonists DAGO and DADLE. Neutrophils with low aminopeptidase activity incubated with MENK released less, while neutrophils with high aminopeptidase activity incubated with MENK released more superoxide anion then the respective control. Thus the level of aminopeptidase activity correlated with the effect of MENK on superoxide anion release.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA