Naslov
Spectral densities and frequencies in the power spectrum of higher order repeat alpha satellite in human DNA molecule

Autori
Paar, Vladimir ; Pavin, Nenad ; Basar, Ivan ; Rosandić, Marija ; Luketin, Ivica ; Durajlija-Žinić, Sonja

Izvornik
Croatica chemica acta (0011-1643) 77 (2004), 1/2; 73-81

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
spectral density ; power spectrum ; human DNA ; alpha satellite ; higher order repeat ; GenBank ; human chromosome 7

Sažetak
Fast Fourier transform was applied to the central segment of a fully equenced genomic segment from the centromeric region in human chromosome 7 (GenBank/ AC017075.8, 193277 bp), which is characterized by alpha satellite higher order repeats (HOR). Frequencies and spectral densities were computed for all prominent peaks in the Fourier spectrum.We have additionally introduced a peak to noise ratio as effective spectral density in order to account for frequency variations of the noise level. We have shown that a very good description of computed Fourier frequencies can be obtained by using the multiple formula with the fundamental frequency corresponding to the 2734-bp HOR sequence. The peak at f16 corresponds to the 171-bp monomer. Above the frequency f16, the most pronounced peaks are mostly at multiples of f16 (monomer-multiples). The lowest sixteen monomer-multiples kf16 are locally dominant in spectral densities. The first monomer-multiple that is not locally dominant in spectral density is at k=17. Above k=27, the maximum of spectral density is systematically shifted to several neighboring higher frequency multiples. On the basis of Fourier spectrum, the 171-bp monomer unit was subdivided into three approximately 57-bp subrepeats, whioch are further subdivided into 12-bp, 14-bp and 17-bp basic subrepeats.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija

POVEZANOST RADA