Naslov
New bone induction by demineralized bone matrix in immunosuppressed rats

Autori
Marušić, Ana ; Đikić, Ivan ; Vukičević, Slobodan ; Marušić, Matko

Izvornik
Experientia (0014-4754) 48 (1992); 783-785

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bone matrix ; Osteoinduction ; Thymectomy ; Irradiation ; Bone marrow reconstitution ; Immunosuppression

Sažetak
Subcutaneous implantation of demineralized bone matrix (DBM) initiates a sequence of developmental events which culminate in endochondral bone formation.To test the effects of T-cell deficiency on new bone formation, the morphology of DBM- induced bone was examined in rats thymectomized at three weeks of age and in thymectomized or nonthymectomized rats lethally irradiated and reconstituted with syngenic bone marrow.At 24 days after implantation, bone induction in control rats was appropriate for their age, while thymectomized-irradiated- reconstituted rats and thymectomized rats had significantly more new bone and larger bone marrow space than the controls.In non-thymectomized, irradiated and reconstituted rats, bone induction occurred in only 25% of the animals, compared to 95% in other groups.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA