Naslov
Acute zinc deficiency and trabecular bone loss in rats with talc granulomatosis

Autori
Marušić, Ana ; Kos, Ksenija ; Stavljenić Rukavina, Ana ; Vukičević, Slobodan

Izvornik
Biological trace element research (0163-4984) 29 (1991), 2; 165-173

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acute zinc deficiency ; trabecular bone loss ; granulomatous inflammation ; rat

Sažetak
Subcutaneous inflammation induced by magnesium silicate (talc) leads to suppression of bone elongation, osteoblast insufficiency, and subsequent bone loss in rats.Since bone and immunological changes in talc granulomatosis are similar to those observed in zinc deficiency, we investigated the kinetics ot zinc tissue distribution and the effects of zinc supplementation on the development of bone loss in rats with talc-induced inflammation.Decrease in serum zinc concentration was observed between 5 and 15 h in rats with talc granulomatosis.It was paralleled by the accumulation of zinc in the liver and rapid disappearance of osteoblats from the trabecular bone surfaces.However, talc- injected rats supplemented parenterally and orally with zinc sulfate exhibited a decrease in osteoblast trabecular surface comparable to that of unsupplemented rats bearing granulomas despite normalized serum zinc concentrations.Zinc supplementation slightly increased osteoblast trabecular surface in all supplemented groups, but this effect was not significant.We conclude that zinc is the earliest indicator of the acute- phase response in rats with talc granulomatosis.Although zinc apperas to be important for the normal function of bone cells, there is no causative relationship.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA