Naslov
Performance of WHO Angina Questionnaire in Measuring Burden of Coronary Heart Disease in Human Isolate Populations

Autori
Biloglav, Zrinka ; Ivanković, Davor ; Campbell, Harry ; Rudan, Igor

Izvornik
Collegium Antropologicum (0350-6134) 28 (2004), 1; 205-213

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
humans; isolate populations; burden of disease; prevalence; CHD; WHO Rose angina questionnaire; screening; validity

Sažetak
Isolated human populations represent good candidates for studying genetic and environmental causes of common complex diseases because the genetic and environmental diversity has been decreased. It has been shown that such populations occasionally exhibit increased prevalence of certain diseases, which is potentially caused by rare genetic variants of large effect brought to common population frequencies by joint action of founder effect, genetic drift and inbreeding and therefore good mapping candidates. Since the registration of the most common diseases in population are rarely covered with viable disease registries, the possibility of inexpensive and reliable detection of disease prevalence in such populations is therefore of considerable importance. In this study, we validated the performance of the WHO Rose Angina Questionnaire (RQ), in measuring burden of coronary heart disease (CHD) in 9 villages of the Croatian Adriatic islands. The definite diagnosis of CHD was defined as myocardial infarction (MI) diagnosed by a specialist in the local general hospital, or angina pectoris (AP) by a local general practitioner (GP). The "true" prevalence of CHD in 1, 001 adult persons was 10, 5%. The results of the RQ screening based on the first 3, 5 and 6 questions were compared with medical record of CHD. Increase in number of RQ questions from 3 to 6 resulted in decreased test sensitivity (from 59.0% to 30.5%) and increased test specificity (from 86.3% to 93.0%) in prediction of true CHD status, which was expected. CHD prevalence was overestimated by 76% when subset of the first 3 questions of RQ was used and by 25% when the first 5 questions were used. However, it was underestimated by 10% when the first 6 questions were used. We conclude that RQ is a useful screening method for measuring burden of CHD in isolate human populations, and that the result based on the first 6 questions is a good approximation of the true CHD prevalence in the population, although it should be considered a slight underestimate.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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