Naslov
Tumor suppressor gene E-cadherin and its role in normal and malignant cells

Autori
Pećina-Šlaus, Nives

Izvornik
Cancer cell international (1475-2867) 23 (2003), 3; 17, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
E-cadherin ; CDH1 ; cell adhesion ; wnt signalling

Sažetak
E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E- cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta- catenins and adenomatous poliposis coli gene products. The structure and function of E- cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA