Naslov
Peripheral biochemical markers in Alzheimer's disease

Autori
Pivac, Nela ; Muck-Šeler, Dorotea ; Mimica, Ninoslav ; Mustapić, Maja ; Šagud, Marina ; Folnegović-Šmalc, Vera ; Mihaljević-Peleš, Alma ; Jakovljević, Miro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
12th Association of European Psychiatrists (AEP) Congress Abstract book ; u: European Psychiatry 19 (2004) (S1) ; Poster Session 1: Organic Mental Disorders ; P14 / Ferrero, Francois ; Maj, Mario ; Sartorius, Norman - Amsterdam : Elsevier, 2004, 152s-152s

Skup
Association of European Psychiatrists Congress (12 ; 2004)

Mjesto i datum
Ženeva, Švicarska, 14.04.2004. - 18.04.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
platelet serotonin and monoamine oxidase; plasma cortisol; prolactin and lipids; Alzheimer's disease

Sažetak
Peripheral biochemical abnormalities are associated with Alzheimer's disease (AD). The aim of the study was to elucidate platelet serotonin (5-HT) concentration, platelet monoamine oxidase (MAO) activity, plasma cortisol, prolactin, and plasma lipid levels (cholesterol, triglycerides, low and high density lipoproteins) in drug-free AD patients and healthy subjects. The diagnosis of the probable AD according to NINCDS-ADRDA criteria was established by two psychiatrists according to ICD-10 and DSM-IV-TR criteria. In 34 patients with AD (14 men ; 20 women) and sex and 75 age-matched healthy controls (36 men ; 39 women) platelet 5-HT concentration and platelet MAO activity were determined spectrofluorimetrically, while plasma levels of cortisol and prolactin were determined by a radioimmunoassay, and plasma lipids by a standard laboratory procedures. All participants gave their informed consent. Data, expressed as means ± ; ; ; SD, were evaluated using one-way analysis of variance followed by Tukey's test. Patients with AD had significantly higher platelet 5-HT concentration and platelet MAO activity than healthy subjects, and similar values of plasma cortisol, prolactin and plasma lipid levels as healthy controls. Significantly higher platelet 5-HT values were found in female AD patients than in control women, while platelet MAO activity was increased in male and female AD patients when compared to corresponding controls. The results from our preliminary, ongoing study, support the presumption that alterations in platelet serotonergic (5-HT and MAO), but not in other peripheral biochemical (plasma cortisol, prolactin and lipids) markers are associated with AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne tehničke znanosti, Temeljne medicinske znanosti

Napomena
Doi:10.1016/j.eurpsy.2004.01.008 ; http://dx.doi.org/10.1016/j.eurpsy.2004.01.008

POVEZANOST RADA