Pregled bibliografske jedinice broj: 146810
Expression of FasL molecule in acute and chronic psoriatic plaque
Expression of FasL molecule in acute and chronic psoriatic plaque // 6th Alpe adria symposium on psoriasis
Venecija, 2003. str. 4-4 (predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 146810 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Expression of FasL molecule in acute and chronic psoriatic plaque
Autori
PRPIĆ-MASSARI, L. ; KASTELAN, M. ; GRUBER, F. ; ZAMOLO, G. ; ZAUHAR, G. ; RUKAVINA, D.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
6th Alpe adria symposium on psoriasis
/ - Venecija, 2003, 4-4
Skup
6th Alpe adria symposium on psoriasis
Mjesto i datum
Venecija, Italija, 07.11.2003. - 08.11.2003
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
FasL molecule; psoriasis
Sažetak
Psoriasis is autoimmune skin diseas in which keratinocyte proliferation was initiated by T cell infiltration and activation. Among T cells, CD4+ T cell predominance in exacerbated psoriatic plaques and CD8+ T cells in resolutive lesions are demonstrated. Cell mediated cytotoxicity reactions (CMC) are mediated by perforin and granzyme exocytosis or binding of FasL (CD95L) with Fas receptor (CD95) on target cell. CD8+ T lymphocytes and to a certain degree CD4+ T lymphocytes as well as NK cells mediate in CMC. The role of cytolytic Fas/FasL pathway is recognized in psoriasis but still insufficiently defined. The aim of our investigation was to analyze expression of Fas and FasL molecules in the psoriatic skin lesions and highlight a role of cytotoxicity mediated by this pathway in pathophysiology of disease.
Izvorni jezik
Engleski
Znanstvena područja
Fizika
