Naslov
Colon cancer: gone with the Wnt

Autori
Čačev, Tamara ; Kapitanović, Sanja

Izvornik
Periodicum biologorum (0031-5362) 106 (2004), 3; 233-238

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Wnt signalling; cancer

Sažetak
Colon cancer is a genetic disease, caused by inherited or acquired mutations in different oncogenes and tumor-suppressor genes. In the past decade, extensive efforts have been made to define the molecular mechanisms underlying development and progression of the colon cancer and to identify possible molecular targets for therapy. Molecular studies have shown that activating mutations of the Wnt signaling pathway are responsable for over 90 % of all colorectal cancers. Mutations that lead to activation of this signaling pathway are mostly inactivating APC mutations or activating beta-catenin mutations. These mutations result in stabilization and nuclear accumulation of beta-catenin which forms a complex with T-cell factor/lymphoid enhacing factor (TCF/LEF) transcription factors to activate gene transcription. In this review, we summarize recent insights into the Wnt signaling mechanism, discuss the Wnt regulatory genes that are mutated in human cancer and highlight possible diagnostic tools and therapeutic targets for future cancer menagement.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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