Naslov
5HT-2C receptor polymorphism in suicide victims : association studies in German and Slavic populations

Autori
Štefulj, Jasminka ; Büttner, Andreas ; Kubat, Milovan ; Zill, Peter ; Balija, Melita ; Eisenmenger, Wolfgang ; Bondy, Brigitta ; Jernej, Branimir

Izvornik
European Archives of Psychiatry and Clinical Neuroscience (0940-1334) 254 (2004), 4; 224-227

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5HT-2C receptor; gene; suicidal behaviour; ethnicity

Sažetak
Sustainable observations suggest that suicidal behaviour by itself may have biological correlates, among which those related to the serotonergic synapse hold the key position. Based on the association of suicide and serotonergic dysfunction, it was proposed that genetic mechanisms affecting suicidal behaviour could be related to the alternations in the genes encoding the elements of 5HT synapse. The present study tested the association of the polymorphism in the serotonin 2C (5HT-2C) receptor coding region (Cys23Ser) with suicide commitment. Study was based on two independent samples, one of German (284 suicide victims versus 297 controls) and other of Slavic/Croatian (118 suicide victims versus 275 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated. Results did not provide supporting evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA