Naslov
Tissue zinc dynamics during the immune reaction in mice

Autori
Verbanac, Donatella ; Milin, Čedomila ; Radošević-Stašić, Biserka ; Trobonjača, Zlatko ; Domitrović, Robert ; Giacometti, Jasminka ; Petković, Marija ; Ćuk, Mira ; Ciganj, Zlatko ; Rupčić, Jasminka ; Rukavina, Daniel

Izvornik
Biological trace element research (0163-4984) 65 (1998), 2; 97-108

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
zinc; ICP spectroscopy; atomic absorption; zinc in tissue; humoral and cellular type of immunity; plaque forming cells generation; local host versus graft reaction

Sažetak
Owing to the importance of zinc for the functioning of the immune system, the role of endogenous Zn, located both in lymphoid and nonlymphoid organs, was investigated during the standard humoral and cellular types of immune response. For this purpose, the dynamics of hepatic, thymic, splenic, and renal Zn content was determined in mice sensitized with (a) sheep red blood cells and (b) semiallogeneic lymphocytes during the local host vs graft reaction (HVGR). The data obtained by ion-coupled plasma spectrometry revealed that the humoral type of immunity is characterized by a significant increase of Zn concentration in the liver and in the thymus. Simultaneously, linear regression analysis showed that the generation of plaque-forming cells in the individual mouse was highly positively correlated with Zn concentration in the liver (r=0.897), and spleen (r=0.833), and negatively with Zn concentration in the thymus (r=-0.624). Similar relationships between the intensity of local immune reaction and tissue Zn levels were found in local HVGR at the fifth day in the liver and spleen (r=0.861 and r=0.695, respectively), at the seventh day in the thymus (r=-0.797), and at the tenth day in the liver (r=-0.859). The data emphasize the necessity of Zn for the development of normal immune response and point to the existence of a Zn-dependent hepato-thymic axis during the humoral and cellular types of immune reactivity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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