Naslov
Dynamic organization of the actin cytoskeleton in Dictyostelium

Autori
Weber, Igor

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Recent Research Developments in Molecular Cellular Biology

Urednik/ci
Pandalai, S.G.

Izdavač
Research Signpost

Grad
Lahti

Godina
2003

Raspon stranica
273-295

ISBN
81-271-0031-5

Ključne riječi
Dictyostelium, actin, cytoskeleton, cell motility, cell division

Sažetak
An overview of recent studies on function of actin-binding proteins conducted in amoeboid cells of Dictyostelium discoideum will be given. Creation of mutants and their phenotypic analysis have led to significant advances in our understanding of how actin-binding proteins function in a cellular environment. Monitoring of the dynamic localization of GFP-fusion proteins has provided important clues about the turnover rates and transport processes within the actin cytoskeleton, in particular by observation of spontaneously occuring spatio-temporal patterns and by FRAP experiments. Cryoelectron tomography of intact eukaryotic cells is an emerging technique that enables examination of the native cytoskeleton structure at an unprecedented detail. Pioneering results obtained from Dictyostelium cells will be presented and prospects of the method discussed.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA