Pregled bibliografske jedinice broj: 143070
Some future aspects of research: heterochromatic DNA, siRNAs and chromatin silencing
Some future aspects of research: heterochromatic DNA, siRNAs and chromatin silencing // 2. Znanstveni simpozij s međunarodnim sudjelovanjem-45 godina molekularne biologije u Hrvatskoj, 50 godina dvostruke uzvojnice-Knjiga sažetaka / Ambriović Ristov, Andreja ; Brozović, Anamaria (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 143070 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Some future aspects of research: heterochromatic DNA, siRNAs and chromatin silencing
Autori
Ugarković, Đurđica
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
2. Znanstveni simpozij s međunarodnim sudjelovanjem-45 godina molekularne biologije u Hrvatskoj, 50 godina dvostruke uzvojnice-Knjiga sažetaka
/ Ambriović Ristov, Andreja ; Brozović, Anamaria - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003
Skup
2. Znanstveni simpozij s međunarodnim sudjelovanjem-45 godina molekularne biologije u Hrvatskoj, 50 godina dvostruke uzvojnice
Mjesto i datum
Zagreb, Hrvatska, 20.11.2003. - 21.11.2003
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
heterochromatin; siRNA; satellite DNA
(heterochromatin; siRNA; satellite DNA; chromatin-modifying enzymes)
Sažetak
Heterochromatic DNA, composed mostly of tandemly repeated sequences or satellite DNAs, encompasses the pericentromeres as well as regions of centromere in most eukaryotes. It differs significantly in sequence and composition even between closely related species. Recent results suggest that satellite DNA evolution is driven by stochastic process and by selective pressure and proceeds in a manner that retains some architectural features or structural domains. It is probably followed by adaptive evolution of the corresponding DNA binding proteins like specific centromeric histones. In addition to the performing a structural role, heterochromatic DNA is transcribed in a developmentally regulated manner. Processed transcripts in the form of small interfering RNAs (siRNAs), 20-24 nt long, trigger the formation of silent chromatin (heterochromatin). This is probably achieved by recruitment of chromatin-modifying enzymes that promote histone methylation necessary for the heterochromatin formation and centromere function. In this way, heterochromatic DNA, through siRNA transcripts, acts as an epigenetic signal for the establishment of chromatin organization required for chromosome segregation. Further studies are needed in order to get a deeper understanding of the biological role of heterochromatic DNA and siRNAs.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
