Naslov
Salivary levels of chemokines in periodontitis

Autori
Bošnjak, Andrija ; Sistig, Suzana ; Vučićević-Boras, Vanja ; Lukač, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of Europerio ; u: Journal of clinical periodontology 30 (2003) (S4) ; Posters ; 19-100 / - , 2003, 28-28

Skup
Europerio

Mjesto i datum
Berlin, Njemačka, 19.06.2003. - 21.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
periodontitis; chemokines

Sažetak
Inflammatory mediators form a group of proteins actively involved in an inflammatory process. Little is known, however, on their levels in saliva in periodontitis-affected individuals. In order to establish their presence and concentrations, we measured the levels of alkaline phosphatase (ALP), lactoferrin (LF), myeloperoxidase (MPO), interleukin-1 (IL-1), and GRO-α in patients with periodontal disease at baseline and after initial treatment (6 weeks). Whole saliva samples were collected at baseline, and six weeks after periodontal treatment in two groups. Study group consisted of 16 subjects with clinical signs and symptoms of periodontitis, while control group consisted of 6 periodontally-healthy individuals. ELISA was performed for assay of MPO, LF and ALP identification and measurements. GRO-α was identified and analyzed by indirect immunodots using monoclonal antibodies. IL-1 assay was performed using the IL-1 ELISA test. It is well known that some salivary constituents actually derive from gingival crevicular fluid. Risk assessment may help in the prevention of periodontal disease, but difficulties that may arise in procedures of early detection are great. Risk indicators are factors that are not necessarily present as etiologic factors, but are certainly associated with the disease progression. To consider that different inflammatory mediators have a general and well defined role would be too simple, or completely wrong. Gathering of complete information on them remains a challenge, limited by their low levels of expression which is usual for most of the cytokines. Finally, it seems that, like most other proteins in the human body, inflammatory mediators have different functions in different tissues and conditions. It is impossible to investigate just some of the inflammatory mediators in the periodontal disease. When the many other inflammatory factors, prostaglandins in the first place, are also taken into account, it is clear that our data do not show the whole mechanism that leads to the periodontal breakdown. However, the whole cytokine network in the pathogenesis of periodontal destruction provides much stimulation to the research, and this is an attempt to add to the scientific knowledge in this field.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Dentalna medicina

Napomena
DOI: 10.1034/j.1600-051X.30.s4.5.x

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