Naslov
Complex Segregation Analysis of Blood Pressure in Three Middle Dalmatian Islands, Croatia

Autori
Škarić-Jurić, Tatjana ; Ginsburg, Emil ; Kobyliansky , Eugene ; Malkin, Ida ; Smolej Narančić, Nina ; Peričić, Marijana ; Rudan, Pavao

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
American Journal of Human Genetics / Warren, Stephan T. - Chicago (IL) : Cell Press, 2003, 371-371

Skup
53rd Annual Meeting of the American Society of Human Genetics

Mjesto i datum
Los Angeles (CA), Sjedinjene Američke Države, 04.11.2003. - 08.11.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
genetic epidemiology; complex segregation analysis; blood pressure; hypertension; Middle Dalmatia; Croatia

Sažetak
Complex segregation analyses of systolic and diastolic blood pressure have been performed on family data from the populations of the islands of Brač, Korčula and Vis (Middle Dalmatia, Croatia), separately, with the purpose to elucidate a potentially promising population for the search of the genes responsible for high prevalence of hypertension present in those populations. The prevalence of hypertension, according to the criteria for developed hypertension (systolic BP > 160 and/or diastolic BP > 95 mm Hg), range from 33.3% on Brač, to 39.9% on Korčula and 40.4% on Vis (36.5% for all islands). Complex segregation analysis has been performed by implementation of the program package MAN. The family sample encompassed 927 individuals, aged 17 - 85 yr. (490 from Brač, 281 from Korčula and 156 from Vis). By applying the usual transmission probability tests, the major gene (MG) hypothesis for systolic and for diastolic blood pressure has been accepted only in the sample from the island of Vis. For both blood pressures, the major gene as well as environmental hypotheses have been rejected in the sample from the island of Korčula, while on the sample from Brač, along with the rejection of MG model, the environmental model - indicating action of polygenetic and environmental family factors - could not be rejected. According to the estimates revealed from the non-constrained MG model, in the sample from the island of Vis, the proportion of (age and sex adjusted) variance of blood pressure that could be attributed to the effect of a hypothetical major gene (H2) is 42.0% for systolic and 47.6% for diastolic blood pressure. The respective values for total genetic variance (h2) are 76.5% and 63.4%. High prevalence of hypertension combined with the results of the complex segregation analyses of blood pressure in three isolated Middle Dalmatia islands point to the island of Vis, as a potentially promising target population for incoming molecular genetic studies of hypertension.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija

POVEZANOST RADA