Naslov
Newly synthesized adamantyl tenocyclidines as effective radioprotectors and antitumor agents

Autori
Ferle-Vidović, Ana ; Škare, Danko ; Šuman, Lidija ; Jukić, Ivan ; Vuković, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
45 godine molekularne biologije u Hrvatskoj 50 godina dvostruke uzvojnice - Drugi znanstveni simpozij sa međunarodnim sudjelovanjem - Knjiga sažekata / Ambriović Ristov, Andreja ; Brozović, Anamaria - Zagreb : Institut Ruđer Bošković, 2003

Skup
45 godine molekularne biologije u Hrvatskoj 50 godina dvostruke uzvojnice - Drugi znanstveni simpozij sa međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 20.11.2003. - 21.11.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
adamantyl derivatives; radioprotection; anticancer drugs

Sažetak
Several adamantyl derivatives of thienyl phencyclidine (tenocyclidine ; TCP) were newly synthesized and characterized:adamantyl derivatives containing piperidine (TAPIP), pyrrolidine (TAPYR), and morpholine (TAMORPH) groups. Their biological activity was evaluated by in vitro testing of their effect on the proliferative and reproductive ability (cytotoxicity) of a human tumor cells strain and nonmalignant mouse fibroblasts in culture. We also tested them for their radioprotective effect after ionizing irradiation, and as anticancer agents on the same human tumor cell strain. Compared with TCP, adamantyl derivatives are less toxic and have outstanding radioprotective properties. These derivatives (especialy TAMORPH) increase apoptotic death of human malignant cells. The radiation-modifying effect studied on C3Hf mice in vivo showed that the adamantyl derivatives of TCP have a more enhanced radioprotective effect and that they are less toxic than TCP itself. The present data are discussed and compared with those previously reported for structurally related phencyclidine derivatives.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA