Naslov
Interindividualne razlike u farmakokinetici teofilina kod djece s akutnom astmom - Predviđanje režima doziranja teofilina
(Interindividual changes in theophylline pharmacokynetics in acute asthmatic children: theophylline dosage predicition)

Autori
Dodig, Slavica ; Plavšić, Franjo ; Čepelak, Ivana ; Raos, Miljenko ; Demirović, Jadranka

Izvornik
Acta Pharmaceutica (1330-0075) 43 (1993), 1; 35-42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
teofilin; predviđanje doze; akutna astma u djece
(theophylline; dosage prediction; acute asthma in children)

Sažetak
Using fluorescence polarization immunoassay, theophylline serum concentration and theophylline pharmacokinetics after a single iv infusion of theophylline were determined in children (n=30), aged 1-10y with severe bronchoobstruction. Pharmacokinetic constants and therapy simulation were calculated on an M 24 Olivetti personal Computer. A dose of 5 mg pf theophylline (Aminophylline, Lek)per kg body mass resulted in therapeutic concentration in only six children, 45 minutes after the end of infusion. In five children, it persisted after 60 minutes, but after 300 minutes therapeutic therapeutic concentration was present in one child only. According to the results of theophylline therapy simulation in acute bronchoobstruction, optimal theophylline serum concentration should be achieved by a continuous iv infusion of 2 +/- 1 mg/kg/h. Interindividual differences in theophylline pharmacokinetics necessitate serum theophylline measurement and individual dosing.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

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