Naslov
Ispitivanje aktivnosti nekih enzima kod primjene teofilina
(A study of some enzyme activities associated with theophylline administration.)

Autori
Dodig, Slavica ; Čepelak, Ivana ; Demirović, Jadranka ; Raos, Miljenko ; Plavšić, Franjo ; Šoštarić, Branko ; Lipej, Zoran

Izvornik
Acta pharmaceutica (1330-0075) 44 (1994); 45-51

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
teofilin ; enzimska aktivnost ; štakori
(theophylline ; enzyme activities ; rats)

Sažetak
In this study, rats were given theophylline at a dose of 15 mg/kg body mass in order to assess the possible adverse effects of the drug. Catalytic activities of AST, ALT, LDH and ALP were measured in the serum and liver of the animals at various time intervals (45, 60 and 300 min). The cumulative effect of theophylline, after a three-day application of the drug, was also studied. Livers of all studied animals were histopathologically examined. The catalytic acitivities of AST and LDH were increased in serum as early as after 60 min, and ALP in liver. Pathohystologic examination of the liver following the cumulative effect of theophylline revealed mild degenerative alterations. With increased doses of theophylline, undesired effects of the drug on the liver could be relativel< early predicted by the measurement of catalytic activities of AST and LDH in serum

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

Napomena
Rad u čsopisu prema Pravilniku NN 2/97.

POVEZANOST RADA