Naslov
Enzimi u serumu djece karakterizirane brzim odnosno sporim acetiliranjem izonijazida
(Enzymes in serum of children characterized by fast and slow isoniazid acetylation)

Autori
Dodig, Slavica ; Medar-Lasić, Maja ; Zimić, Lukrica ; Živčić, Jadranka ; Čepelak, Ivana

Izvornik
Acta Pharmaceutica (1330-0075) 45 (1995); 69-74

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
enzimi; acetilacija izonijazida; plućna tuberkuloza u djece
(enzymes; isoniazid acetylation; lung tuberculosis in children)

Sažetak
For 12 weeks the catalytic activities of AST, ALT, GGT an alkaline phosphatase have been monitored on sera of 69 children on antituberculotic therapy (fast isoniazid acetylators, n=33) ; slow isoniazid acetylators, n= 36). A significant increase has been most frequently observed in the activities of AST, ALT in sera of both phenotypes throughout the period of treatment. The determination of the catalytic activities of GGT is found to be justified in both phenotypes, and those of alkaline phosphatase in the slow acetylators depending on the drug added to the isoniazid therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

Napomena
Rad u čsopisu prema Pravilniku NN 2/97.

POVEZANOST RADA