Naslov
Crohn's disease of the esophagus visualized by Tc-99m antigranulocyte antibodies

Autori
Huić, Dražen ; Dodig, Damir ; Premuzić, Marina ; Krznarić, Željko ; Vucelić, Boris

Izvornik
Clinical Nuclear Medicine (0363-9762) 27 (2002), 11; 810-811

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, stručni

Ključne riječi
Crohn's disease; Crohn's esophagitis; Scintigraphy; Tc-99m antigranulocyte antibodies

Sažetak
A 49-year-old oman with a 20 year history of Crohn's disease reported progressive dysphagia, retrosternal chest pain, and moderate eight loss. Esophagoscopy revealed diffuse erythema with mucosal inflammation and friability. Endoscopy findings were reportedas esophagitis because focal inflammation was present. Radiologic studies showednormal small bowel transit and fistula between the rectum and vagina. To estimate the spread of the disease, a scintigraphic study with Tc-99m-labeld anti-NCA 95 antigranulocyte antibodies (AGAb) was performed (0.5 mg/BW, 250/183 ; intract murine antibody, IgG1 isotype ; CIS Biointernational, Dreieich, Germany). On the planar scans, prominent AGAb uptake in the entire esophagus was observed, suggesting Crohn's esophagitis. After treatment ith methylprednisolone and mesalamine, the patient's symptoms resolved.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA